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Citric Acid/Sodium Bicarbonate

Brand Name: Alka-Seltzer Heartburn Relief
Generic Name: Citric Acid/Sodium Bicarbonate
Drug Class: Antacids, Combos

What Is Citric Acid/Sodium Bicarbonate and How Does It Work?

Citric acid/sodium bicarbonate is an over-the-counter (OTC) product used for indigestion/heartburn.

Citric acid/sodium bicarbonate is available under the following different brand names: Alka-Seltzer Heartburn Relief.

Dosages of Citric Acid/Sodium Bicarbonate:

Dosage Forms and Strengths

Effervescent Tablet

  • 1000mg/1940mg

Dosage Considerations – Should be Given as Follows:


  • Adults and children 12 years and older: Dissolve 2 tablets in water and drink effervescent solution every 4 hours as needed
  • Not to exceed 8 tablets/24 hours
  • Adults over 60 years: Not to exceed 4 tablets/24 hours
  • Children under 12 years: Safety and efficacy not established


  • Fully dissolve tablets in 4 oz of water before drinking

What Are Side Effects Associated with Using Citric Acid/Sodium Bicarbonate?

Citric acid/sodium bicarbonate has no listed side effects.  

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Citric Acid/Sodium Bicarbonate?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Citric acid/sodium bicarbonate has no listed severe interactions with other drugs.

Serious interactions of citric acid/sodium bicarbonate include:

  • atazanavir
  • baloxavir marboxil
  • pazopanib
  • ponatinib

Moderate interactions of citric acid/sodium bicarbonate include:

  • budesonide
  • dabrafenib
  • ledipasvir/sofosbuvir
  • nilotinib
  • omadacycline
  • pexidartinib
  • riociguat
  • sarecycline
  • sofosbuvir/velpatasvir

Citric acid/sodium bicarbonate has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.


Digestive Disorders: Common Misconceptions See Slideshow

What Are Warnings and Precautions for Citric Acid/Sodium Bicarbonate? 


This medication contains citric acid/sodium bicarbonate. Do not take Alka-Seltzer Heartburn Relief if you are allergic to citric acid/sodium bicarbonate or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


  • None

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Citric Acid/Sodium Bicarbonate?”

Long-Term Effects

  • See "What Are Side Effects Associated with Using Citric Acid/Sodium Bicarbonate?”


  • Sodium-restricted diet; 575 mg sodium/tablet
  • Phenylketonurics; contains phenylalanine 5.6 mg/tablet
  • Discontinue if taken maximum dosage for 2 weeks without relief
  • Alters gastric pH and may interfere with absorption of some concurrent medications

Pregnancy and Lactation

Use citric acid/sodium bicarbonate with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.

It is unknown whether citric acid/sodium bicarbonate is distributed in breast milk.

Pregnant or breastfeeding patients should seek advice of a health professional before using over-the-counter (OTC) drugs.
Reviewed on 3/24/2020

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