Brand Name: Norvasc
Generic Name: amlodipine
Drug Class: Calcium Channel Blockers; Antianginal Agents
What Is Amlodipine and How Does It Work?
Amlodipine a prescription medication that is used with or without other medications to treat high blood pressure. Lowering blood pressure helps prevent strokes, heart attacks, and kidney problems. Amlodipine belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily.
Amlodipine is also used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor.
Amlodipine is available under the following different brand names: Norvasc.
Dosages of Amlodipine Should Be Given As Follows:
Adult and Pediatric Dosage Forms & Strengths
- 2.5 mg
- 5 mg
- 10 mg
Hypertension (High Blood Pressure)
- 5 mg/day orally initially; may be increased by 2.5 mg/day every 7-14 days; not to exceed 10 mg/day orally; maintenance: 5-10 mg/day orally
- Children under 6 years: Safety and efficacy not established
- Children 6 years and older: 2.5-5 mg/day orally
- 2.5-5 mg/day orally initially; may be increased by 2.5 mg/day every 7-14 days; not to exceed 10 mg/day orally; maintenance: 5-10 mg/day orally
Coronary Artery Disease
Treatment of chronic stable angina and vasospastic angina (Prinzmetal or variant angina) and angiographically documented coronary artery disease (CAD) in patients without heart failure or ejection fraction (EF) less than 40%
- 5-10 mg/day orally initially; maintenance: 10 mg/day orally
- 2.5-10 mg/day orally initially; maintenance: 10 mg/day orally
- 5-10 mg/day orally; maintenance: 10 mg/day orally
- 2.5-10 mg/day orally; maintenance: 10 mg/day
Hepatic insufficiency: Consider starting with 2.5 mg/day orally
Severe hepatic impairment: Titrate slowly
What Are Side Effects Associated with Using Amlodipine?
Side effects of amlodipine include:
- Swelling (edema)
- Excess fluid in the lungs (pulmonary edema)
- Abdominal pain
- Male sexual disorder
- Skin rash
- Muscle cramps
- Muscle weakness
Postmarketing side effects of amlodipine reported include:
- Extrapyramidal disorder (muscle spasms, restlessness, muscle rigidity, slow movement, tremor, and jerky movements)
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
What Other Drugs Interact with Amlodipine?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Severe Interactions of amlodipine include:
Serious Interactions of amlodipine include:
Amlodipine moderate interactions with at leas 92 different drugs.
Amlodipine moderate interactions with at leas 100 different drugs.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
What Are Warnings and Precautions for Amlodipine?
This medication contains amlodipine. Do not take Norvasc if you are allergic to amlodipine or any ingredients contained in this drug.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
Effects of Drug Abuse
See "What Are Side Effects Associated with Using Amlodipine?"
See “What Are Side Effects Associated with Using Amlodipine?”
Extensively metabolized by liver; titrate dose slowly with severe hepatic impairment.
Initiate at lower dose in the elderly.
Titrate dose every 7-14 days on a given dose; peak antihypertensive effect is delayed.
Co-administration with CYP3A inhibitors (moderate and strong) results in increased systemic exposure to amlodipine and may require dose reduction; monitor for symptoms of hypotension and edema when amlodipine is co-administered with CYP3A inhibitors to determine the need for dose adjustment.
Amlodipine may increase systemic exposure of cyclosporine or tacrolimus when co-administered; frequent monitoring of trough blood levels of cyclosporine and tacrolimus recommended; adjust dose when appropriate
Pregnancy and Lactation
It is unknown whether amlodipine is excreted in milk; use of amlodipine while breastfeeding is not recommended.
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