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Anastrozole

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Brand Name: Arimidex

Generic Name: anastrozole

Drug Class: Antineoplastics, Aromatase Inhibitor

What Is Anastrozole and How Does It Work?

Anastrozole is a non-steroidal aromatase inhibitor used to treat breast cancer in postmenopausal women. Anastrozole is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).

Anastrozole is available under the following different brand names: Arimidex.

Dosages of Anastrozole:

Dosage Forms and Strengths

Tablet

Dosage Considerations – Should be Given as Follows:

Breast Cancer

Postmenopausal women

Advanced

  • 1 mg orally once daily; continue until tumor progression

Early

Administration

  • May be taken with or without food

Hepatic Impairment

  • Mild-to-moderate impairment or stable hepatic cirrhosis: Dose adjustment not necessary
  • Severe hepatic impairment: Not studied

Pediatric: Use not recommended

What Are Side Effects Associated with Using Anastrozole?

Side effects of anastrozole include:

Less common side effects of anastrozole include:

  • Accidental injury
  • Back pain
  • Fracture
  • Headache
  • Trouble sleeping (insomnia)
  • Swelling of extremities
  • Shortness of breath
  • Abdominal pain
  • Infection
  • Enlarged lymph nodes
  • Diarrhea
  • Constipation
  • Dizziness
  • Urinary tract infection (UTI)
  • Chest pain
  • Indigestion
  • Numbness and tingling
  • Anxiety
  • Cataracts
  • Flu syndrome
  • Sinus infection (sinusitis)
  • Vulvovaginitis
  • Dry mouth
  • Bronchitis
  • Cyst
  • Increased sweating
  • New and abnormal tissue growth
  • Vaginal bleeding
  • Fractures of spine, hip, or wrist
  • Ischemic cardiovascular disease
  • Vaginal discharge
  • Vaginitis
  • Deep vein thrombosis (DVT)
  • Endometrial cancer (intact uterus at baseline)
  • Ischemic cerebrovascular event
  • Weight gain/weight changes
  • Lethargy
  • Postmarketing side effects of anastrozole reported include:

    This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

    What Other Drugs Interact with Anastrozole?

    If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

    Severe Interactions of anastrozole include:

    • None

    Serious Interactions of anastrozole include:

    • bazedoxifene/conjugated estrogens
    • conjugated estrogens
    • estradiol
    • estrogens conjugated synthetic
    • estrogens esterified
    • estropipate
    • ethinylestradiol
    • tamoxifen

    Moderate Interactions of anastrozole include:

    Mild Interactions of anastrozole include:

    • ruxolitinib

    This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

    What Are Warnings and Precautions for Anastrozole?

    Warnings

    • This medication contains anastrozole. Do not take Arimidex if you are allergic to anastrozole or any ingredients contained in this drug.
    • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

    Contraindications

    • Hypersensitivity
    • May cause fetal harm or loss; use is contraindicated in women who are or may become pregnant

    Effects of Drug Abuse

    • No information available

    Short-Term Effects

    • See "What Are Side Effects Associated with Using Anastrozole?"

    Long-Term Effects

    • Decreases lumbar spine and total hipbone mineral density; increased risk of fractures and osteoporosis
    • See "What Are Side Effects Associated with Using Anastrozole?"

    Cautions

    • Increased incidence of ischemic cardiovascular events in women with preexisting ischemic heart disease; use only if benefits greatly outweigh risks
    • Decreases lumbar spine and total hipbone mineral density; increased risk of fractures and osteoporosis
    • Elevated serum cholesterol reported; monitor closely
    • Affords no clinical benefit to premenopausal women with breast cancer
    • Increased risk of ischemic cardiovascular events in patients with pre-existing ischemic cardiac disease

    Pregnancy and Lactation

    • Do not use anastrozole in pregnancy. The risks involved outweigh potential benefits. Safer alternatives exist
    • It is unknown whether anastrozole is excreted in milk; it is not recommended given potential for serious adverse reactions in nursing infants
    Reviewed on 5/1/2017

    Medscape. Anastrozole.
    https://reference.medscape.com/drug/arimidex-anastrozole-342208
    RxList. Arimidex Side Effects Center.
    https://www.rxlist.com/arimidex-side-effects-drug-center.htm

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