Artificial Saliva

Reviewed on 9/8/2021

What Is Artificial Saliva Used For and How Does it Work?

Artificial saliva is an over-the-counter (OTC) product used to treat dry mouth (xerostomia).

Artificial saliva is available under the following different brand names: Oasis, Aquoral, SalivaSure, Caphosol, and XyliMelts.

Dosages of Artificial Saliva

Dosage Forms and Strengths

Oral Spray

Oral Solution

  • Caphosol: Dibasic sodium phosphate 0.032%, monobasic sodium phosphate 0.009%, calcium chloride 0.052%, sodium chloride 0.569%, purified water (30 mL); packaged in two 15 mL ampuls when mixed together provide one 30 mL dose
  • Entertainer's secret: Aloe vera gel, sodium carboxymethylcellulose, glycerin (60 mL); ethanol free; honey-apple flavor


  • SalivaSure: Xylitol, citric acid, apple acid, sodium citrate dihydrate, sodium carboxymethylcellulose, dibasic calcium phosphate, silica colloidal, magnesium stearate, stearic acid
  • Numoisyn: Sorbitol 0.3 g/lozenge; polyethylene glycol, calcium phosphate dibasic, hydrogenated cottonseed oil, silicon dioxide, magnesium stearate, citric acid, malic acid, sodium citrate

Liquid Oral

  • Numoisyn: Chondrus crispus, potassium sorbate, sorbitol, water, linseed extract, sodium benzoate, dipotassium phosphate, propylparaben, methylparaben


  • Biotene Oral Balance: Water, sunflower oil, starch, propylene glycol, glycerine, purified milk extract, xylitol (sugar free)

Discs Extended Release

  • XyliMelts: 500 mg xylitol: Dye free, gluten free, preservative free, soy free, yeast free

Powder for Reconstitution

  • NeutraSal: Chloride, silicon dioxide, bicarbonate, sodium, phosphates, calcium

Dosage Considerations – Should be Given as Follows:

Dry Mouth (Xerostomia)

  • Caphosol, NeutraSal: Swish and spit; 2-10 doses/day
  • Oasis spray: 1-2 sprays as needed; not to exceed 60 sprays/day
  • Oasis mouthwash: Rinse mouth with approximately 30 mL every 12 hours as needed; do not swallow
  • Aquoral: 2 sprays orally every 6-8 hours as needed
  • Entertainer's secret: Spray as needed
  • Mouth Kote spray: Spray 3-5 times; swish for 8-10 seconds and spit or swallow as needed
  • Biotene: Apply 0.5-inch length onto tongue and spread evenly; repeat as often as needed
  • Numoisyn liquid: Use 2 mL as needed
  • Numoisyn lozenges: Dissolve 1 lozenge slowly; not to exceed 16 lozenges/day
  • SalivaSure: Dissolve 1 lozenge in mouth as needed; 1 lozenge/hour recommended
  • XyliMelts: Apply 2 discs before bed, 1 on each side of mouth, in lower or upper part of cheek; during the day, use as needed; swallow as it slowly dissolves (the tan, dimpled side will adhere to teeth or gums); before bedtime, use 2 discs, placing one on each side of the mouth

Safety and efficacy not established in pediatric patients.


What causes tooth decay? See Answer

What Are Side Effects Associated with Using Artificial Saliva?

Common side effects of Artificial Saliva include:

  • Altered speech
  • Abnormal taste
  • Digestive problems
  • Difficulty swallowing

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Artificial Saliva?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Artificial Saliva has no listed severe interactions with other drugs.
  • Artificial Saliva has no listed serious interactions with other drugs.
  • Artificial Saliva has no listed moderate interactions with other drugs.
  • Artificial Saliva has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Artificial Saliva?


This medication contains artificial saliva. Do not take Oasis, Aquoral, SalivaSure, Caphosol, or XyliMelts if you are allergic to artificial saliva or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


  • Documented hypersensitivity
  • Fructose intolerance (Numoisyn lozenges)

Effects of Drug Abuse

  • No information available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Artificial Saliva?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Artificial Saliva?"


  • Caphosol contains 75 mg of sodium per 30 mL dose

Pregnancy and Lactation

Artificial saliva is generally acceptable for use during pregnancy. Controlled studies in pregnant women show no evidence of fetal risk.

There is no information available on whether artificial saliva passes into breast milk. Consult your doctor before breastfeeding.


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