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Azithromycin

Medical and Pharmacy Editor:

Brand Name: Zithromax, Zmax

Generic Name: azithromycin

Drug Class: Macrolides, a class of antibiotics

What Is Azithromycin and How Does It Work?

Azithromycin is used to treat certain bacterial infections (including sinusitis, pneumonia). It is a macrolide-type antibiotic. It works by stopping the growth of bacteria.

This medication will not work for viral infections (such as common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

Azithromycin is available under the following different brand names: Zithromax, and Zmax.

Susceptible organisms

  • Actinobacillus actinomycetemcomitans, Actinomyces israelii, Actinomyces naeslundii, Actinomyces odontolyticus, Afipia felis, Arachnia propionica, Arcanobacterium (Corynebacterium) haemolyticum, Bartonella henselae, Bartonella quintana, Bordetella pertussis, Borrelia burgdorferi, Borrelia recurrentis, Klebsiella granulomatis, Campylobacter jejuni, Chlamydia pneumoniae (TWAR agent), Chlamydia trachomatis, Haemophilus ducreyi, Haemophilus influenzae, Legionella spp, Mycobacterium simiae, Mycobacterium scrofulaceum, Mycobacterium xenopi, Mycoplasma pneumoniae, Moraxella (Branhamella) catarrhalis, Neisseria gonorrhoeae, Staphylococcus aureus, Streptococcus (group C and G), Streptococcus agalactiae (group B), Streptococcus bovis (group D), Streptococcus intermedius group (Streptococcus anginosus, Streptococcus intermedius, Streptococcus constellatus), Streptococcus pneumoniae, Streptococcus pyogenes (group A), viridans streptococci
  • First-line therapy: A felis, B henselae, B quintana, B pertussis, C jejuni, C pneumoniae (TWAR agent), C trachomatis, H ducreyi, H influenzae, Legionella spp, M scrofulaceum, M simiae, M xenopi, N gonorrhoeae

Dosages of Azithromycin

Adult and Pediatric Dosage Forms & Strengths

Powder for solution

  • 500 mg
  • 25 g

Suspension reconstituted

  • 100 mg / 5mL
  • 200 mg / 5mL

Packet

  • 1 mg

Tablets

  • 250 mg
  • 500 mg
  • 600 mg

Oral suspension, Pediatric

  • 100 mg / 5mL
  • 200 mg / 5mL

Dosage Considerations – Should be Given as Follows:

Acute Bacterial Exacerbations of Chronic Obstructive Pulmonary Disease

500 mg orally once, then 250 mg once daily for 4 days

Alternatively, 500 mg orally once/day for 3 days

Acute Otitis Media

500 mg orally once, then 250 mg once daily for 4 days

Younger than 6 months: Safety and efficacy not established

6 months and older: 30 mg/kg of oral suspension once or 10 mg/kg orally once daily for 3 days or 10 mg/kg once on day 1 followed by 5 mg/kg on days 2-5

Genital Ulcer Disease (Chancroid)

1 g orally once

Acute Bacterial Sinusitis

500 mg/day orally for 3 days or 2 g orally once

Pediatric: Zmax: 2g orally once

10 mg/kg of oral suspension orally once daily for 3 days

Community-Acquired Pneumonia

500 mg orally once, then 250 mg once daily for 4 days

2 g extended release suspension orally once

500 mg intravenously (IV) as single dose for at least 2 days; follow with oral therapy with single dose of 500 mg to complete 7-10 days course of therapy

Younger than 6 months: Safety and efficacy not established

6 months and older: 10 mg/kg orally on day 1, followed by 5 mg/kg orally on days 2 through 5

6 months and older (Zmax): 60 mg/kg orally once; not to exceed 2 g

Pharyngitis/Tonsillitis500 mg orally once, then 250 mg once daily for 4 days

Alternatively, 12 mg/kg orally; not to exceed 500 mg on day 1 followed by 6 mg/kg; not to exceed 250 mg on days 2 through 5

Younger than 2 years: Safety and efficacy not established

2 years and older: 12 mg/kg orally once daily for 5 days; not to exceed 500 mg/day

Uncomplicated Skin/Skin Structure Infections

500 mg orally once, then 250 mg once daily for 4 days

Cat Scratch Disease

Greater than 45.5 kg: 500 mg orally once, then 250 mg once daily for 4 days

Pediatric, off-label: Less than 45.5 kg: 10 mg/kg orally as single dose; then 5 mg/kg orally once/day on days 2 through 5

Less than 45.5 kg: 500 mg orally once, then 250 mg once daily for 4 days

Pertussis (Off-label)

500 mg orally once, then 250 mg once daily for 4 days

Acute Pelvic Inflammatory Disease

500 mg intravenously (IV) over 1 hour once daily for 1-2 days; follow therapy by oral route with 250 mg once/day for 5 days to complete a 7 day therapy

Uncomplicated Gonococcal Infections

Infection of pharynx, cervix, urethra, or rectum: Ceftriaxone 250 mg intramuscularly (IM) once plus azithromycin 1 g orally once (preferred) or alternatively doxycycline 100 mg orally once every 12 hours for 7 days

CDC STD guidelines: MMWR Recomm Rep. June 5, 2015:64(RR3);1-137

Sexual assault

Prophylaxis of sexually transmitted diseases (STDs) such as gonorrhea after sexual assault per CDC guidelines includes the following 3-drug regimen:

  • Ceftriaxone 250 mg intramuscularly (IM) once PLUS
  • Azithromycin 1 g orally once PLUS
  • Metronidazole or tinidazole 2 g orally once
  • If alcohol has been recently ingested or emergency contraception is provided, metronidazole or tinidazole can be taken by the victim at home rather than as directly observed therapy to avoid drug interactions

Mycobacterium Avium Complex Infection

Prevention

  • Primary prophylaxis: 1.2 g orally once weekly or 600 mg orally twice weekly; with or without rifabutin 300 mg once daily
  • Secondary prophylaxis: 500-600 mg orally once/day in combination with ethambutol
  • Younger than 6 years: Safety and efficacy not established
  • 6 years and older primary prophylaxis: 20 mg/kg orally once weekly; not to exceed 1200 mg or 5mg/kg/day once/day; not to exceed 250 mg/day
  • 6 years and older secondary prophylaxis: 5 mg/kg/day orally once/day; not to exceed 250 mg/day in cimbination with ethambutol with or without rifabutin

Treatment

  • 250 mg orally once daily in combination with ethambutol 15 mg/kg/day with or without rifabutin 300 mg/day
  • Alternative regimen: 500 mg orally 3 times weekly in combination with ethambutol 15 mg/kg/day with or without rifabutin 300 mg/day
  • Pediatric: 10-12 mg/kg/day orally; not to exceed 500 mg; used in combination with ethambutol; if severe disease patient should also receive rifabutin

Endocarditis (Off-label)

Prophylaxis

500 mg orally 30-60 min before procedure

Current American Heart Association (AHA) guidelines recommend only for high-risk patients

Chlamydia Trachomatis Infection (Pediatric, Off-label)

Greater than 45 mg/kg: 1 g orally as single dose

Dosage Considerations

Not for use in patients with pneumonia judged to be inappropriate for oral therapy because of moderate to severe illness or risk factors

Medically Reviewed by a Doctor on 4/14/2017



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