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Medical and Pharmacy Editor:

Brand Name: Bumex, Burinex

Generic Name: Bumetanide

Drug Class: Diuretics, Loop

What Is Bumetanide and How Does It Work?

Bumetanide is used to reduce extra fluid in the body (edema) caused by conditions such as congestive heart failure, liver disease, and kidney disease. Getting rid of extra water helps to reduce fluid in the lungs so that you can breathe easier. It also helps to decrease swelling of the arms, legs, and stomach/abdomen. Bumetanide is known as a diuretic (the same kind of drug as a "water pill"). It causes your body to get rid of extra water by increasing the amount of urine you make.

Bumetanide is available under the following different brand names: Bumex, and Burinex.

Dosages of Bumetanide:

Adult and pediatric dosages:

Injectable solution

  • 0.25 mg/ml


  • 0.5 mg
  • 1 mg
  • 2 mg

Dosage Considerations – Should be Given as Follows:

Edema in Adults

  • Orally: 0.5-2 mg once; may be repeated in 4-5 hours for up to 2 doses; not to exceed 10 mg/day
  • Intramuscular: 0.5-1 mg once; may be repeated in 2-3 hours for up to 2 doses; not to exceeded 10 mg/day
  • Intravenously: 1 mg initially, then 0.5-2 mg/hour

Pediatric (off-label)

  • Infants under 6 months: 0.01-0.05 mg/kg once daily or every other day; optimum diuretic effect is reported at 0.04 mg/kg; lower dosages have been shown to have greater efficacy
  • Infants 6 months and older: 0.015-.01 mg/kg once daily or every other day; not to exceed 10 mg/day

Hypertension (off-label)

  • 1 mg intravenous loading dose, then 0.5-2 mg/day orally divided every 12 hours


Dosing Considerations

1 mg bumetanide is roughly equivalent to 40 mg furosemide

  • Edema due to congestive heart failure, hepatic disease, or nephrotic syndrome
    • Use with fluid retention refractory to thiazides or with impaired renal function
    • May be tried if patient is allergic to furosemide

Overdose Management

  • Normal saline may be used for volume replacement
  • Dopamine or norepinephrine may be used to treat hypotension
  • Treat hyperkalemia with intravenous glucose (D25W) with rapid-acting insulin and concurrent intravenous sodium bicarbonate; use oral and rectal solutions of sodium polystyrene in sorbitol if needed
  • If dysrhythmia due to decreased potassium or magnesium is suspected, replace aggressively
  • Discontinue treatment if no symptoms are apparent after 6 hours
Medically Reviewed by a Doctor on 5/17/2017

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