Carbamide Peroxide Oral

Reviewed on 9/17/2021

What Is Carbamide Peroxide Oral Used For and How Does it Work?

Carbamide peroxide oral is an over-the-counter (OTC) product used for canker sores or gum irritation and oral hygiene.

Carbamide peroxide oral is available under the following different brand names: Cankaid, Gly-Oxide, and Orajel Perioseptic.

What Are the Dosages of Carbamide Peroxide Oral?

Dosages of Carbamide Peroxide Oral:

Oral Solution/Liquid

  • 10%
  • 15%
  • 20%

Dosage Considerations – Should be Given as Follows:

Canker Sores or Gum Irritation

  • Adults and children over 2 years
  • Apply several drops to the affected area, expectorate after 2-3 minutes, OR
  • Place 10 drops on the tongue, mix with saliva, swish in mouth for several minutes, then spit out
  • May repeat up to 4 times/day

Oral Hygiene

  • Adults and children over 2 years
  • Liquid 15%: Everyday use; apply to a toothbrush, cover with toothpaste, brush and spit out


Mouth Problems: TMJ, Canker Sores, Painful Gums and More See Slideshow

What Are Side Effects Associated with Using Carbamide Peroxide Oral?

  • Carbamide peroxide oral has no listed side effects.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Carbamide Peroxide Oral?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

What Are Warnings and Precautions for Carbamide Peroxide Oral?


  • This medication contains carbamide peroxide oral. Do not take Cankaid, Gly-Oxide, or Orajel Perioseptic if you are allergic to carbamide peroxide oral or any ingredients contained in this drug.


  • Hypersensitivity

Effects of Drug Abuse

  • No information is available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Carbamide Peroxide Oral?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Carbamide Peroxide Oral?"


  • Overgrowth of opportunistic infections possible with prolonged use
  • Consult dentist or physician if severe or persistent oral inflammation persists

Pregnancy and Lactation

  • Use carbamide peroxide oral with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • Carbamide peroxide oral is not secreted into breast milk.
  • Pregnant or breastfeeding patients should seek the advice of a health professional before using over-the-counter (OTC) drugs.

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