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Capecitabine

Medical and Pharmacy Editor:

Brand Name: Xeloda

Generic Name: Capecitabine

Drug Class: Antineoplastics, Antimetabolite

What Is Capecitabine and How Does It Work?

Capecitabine is a prescription drug used to treat breast, colon, or rectal cancer. It works by slowing or stopping the growth of cancer cells.

Capecitabine is available under the following different brand names: Xeloda.

Dosages of Capecitabine:

Tablet

  • 150 mg
  • 500 mg

Dosage Considerations – Should be Given as Follows:

Duke Stage C Colon Cancer

Adjuvant therapy

  • 1,250 mg/m2 orally twice a day for 2 weeks, followed by 1-week rest period, given as 3 week cycles for a total of 8 cycles (24 weeks)

Colorectal Cancer

Metastatic disease

  • 1250 mg/m2 twice a day for 2 weeks every 21 days

Breast Cancer

Metastatic, resistant to paclitaxel, anthracyclines

  • Monotherapy: 1250 mg/m2 twice a day for 2 weeks every 3 weeks
  • Combo therapy with Docetaxel: 1250 m2 orally twice a day for 2 weeks every 3 weeks plus Docetaxel 75 mg/m2 1 hour intravenous infusion every 3 weeks

Administration

  • Swallow with water within 30 minutes after a meal
  • Dosage may need to be individualized to optimize patient management
Medically Reviewed by a Doctor on 7/26/2017



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