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Captopril

Medical and Pharmacy Editor:

Brand Name: apoten, Captoril

Generic Name: Captopril

Drug Class: ACE Inhibitors

What Is Captopril and How Does It Work?

Captopril is an angiotensin converting enzyme (ACE) inhibitor prescribed for treating high blood pressure, heart failure, and for preventing kidney failure due to high blood pressure and diabetes.

Captopril is available under the following different brand names: Capoten and Captoril.

Dosage of Captopril:

Adult and Pediatric Dosages

Tablet

  • 12.5 mg
  • 25 mg
  • 50 mg
  • 100 mg

Geriatric Dosages

  • 12.5 mg
  • 25 mg

Dosage Considerations – Should be Given as Follows:

Acute Hypertension

Adult and geriatric:

  • 12.5-25 mg orally, may repeat as needed

Hypertension (alone or with Thiazide)

Adults and geriatric:

  • Initial: 25 mg orally every 8-12 hours, increase gradually based on response (may start lower in some patients)
  • Maintenance: 25-150 mg orally every 8-12 hours
  • 450 mg/day maximum

Pediatric (off-label)

  • Neonates: 0.05-0.1 mg/kg/dose every 8-24 hours, titrate dose up to 0.5 mg/kg/dose every 6-24 hours
  • Infants: 0.15-0.3 mg/kg/dose; titrate dose upward to maximum 6 mg/kg/day in 1-4 divided doses; 2.5-6 mg/kg/day usually required
  • Children: 0.3-0.5 mg/kg/dose; titrate to maximum 6 mg/kg/day divided every 6-12 hours
  • Older children: 6.25-12.5 mg/dose every 12-24 hours; titrate to no more than 6 mg/kg/day divided every 6-12 hours
  • Adolescents: 12.5-25 mg/dose every 8-12 hours; may increase by 25 mg/dose every 1-2 weeks to maximum 450 mg/day

Congestive Heart Failure (with Diuretics and Digitalis)

Adult and geriatric:

  • Target therapy: 50 mg every 8 hours
  • 450 mg/day maximum

Left Ventricular Dysfunction After Myocardial Infarction

Adult and geriatric:

  • 6.25 mg orally initially followed by 12.5 mg every 8 hours
  • Increase to 25 mg orally every 8 hours over next few days; THEN
  • Target dose: 50 mg orally every 8 hours

Diabetic Nephropathy

Adult and geriatric:

  • 25 mg orally every 8 hours

Dosing Considerations

Administrations

What Are Side Effects Associated with Using Captopril?

Side effects of captopril include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Captopril?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Captopril has no known severe interactions with other drugs.

Captopril has serious interactions with at least 45 different drugs.

Captopril has moderate interactions with at least 185 different drugs.

Captopril has minor interactions with at least 32 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

What Are Warnings and Precautions for Captopril?

Warnings

  • Discontinue as soon as possible when pregnancy detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
  • This medication contains captopril. Do not take Capoten or Captoril if you are allergic to captopril or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

Contraindications

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Captopril?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Captopril?"

Cautions

Pregnancy and Lactation

  • Use captopril with caution in the first trimester of pregnancy if benefits outweigh risks
  • Animal studies show risk and human studies are not available or neither animal nor human studies were done
  • During the 2nd and 3rd trimesters of pregnancy, use captopril during pregnancy only in LIFE-THREATENING emergencies when no safer drug is available
  • There is positive evidence of human fetal risk
  • Discontinue captopril as soon as pregnancy is detected
  • During the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death
  • Captopril enters breast milk and is not recommended to use while breastfeeding (the American Association of Pediatrics states it is compatible with breastfeeding)
Reviewed on 6/7/2017

Medscape. Captopril.
https://reference.medscape.com/drug/capoten-captoril-captopril-342315#0
RxList. Capoten Monograph.
https://www.rxlist.com/capoten-drug.htm

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