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Medical and Pharmacy Editor:

Brand Name: Kefzol, Ancef

Generic Name: Cefazolin

Drug Class: Cephalosporins, 1st Generation

What Is Cefazolin and How Does It Work?

Cefazolin is an antibiotic used to treat a wide variety of bacterial infections. It may also be used before and during certain surgeries to help prevent infection. This medication is known as a cephalosporin antibiotic. It works by stopping the growth of bacteria.

Cefazolin is available under the following different brand names: Kefzol and Ancef.

Dosages of Cefazolin:

Dosage Forms and Strengths

Powder for injection

  • 500 mg
  • 1 g
  • 2 g
  • 10 g
  • 20 g
  • 100 g
  • 300 g

Dosage Considerations – Should be Given as Follows:

Moderate-to-Severe Infections

  • 0.5-1 g intravenously (IV) every 6-8 hours

Mild Infections With Gram-Positive Cocci

  • Adult: 250-500 mg intravenously (IV) every 8 hours
  • Infants and children: 25-100 mg/kg/day intravenously/intramuscularly (IV/IM) divided every 6-8 hours; not to exceed 6 g/day
  • Neonates (under 28 days)
    • Under 7 days: 40 mg/kg/day IV/IM divided every 12 hours
    • Greater than 7 days, less than 2 kg: 40 mg/kg/day IV/IM divided every 12 hours
    • Greater than 7 days, greater than 2 kg: 60 mg/kg/day IV/IM divided every 8 hours

Mild-to-Moderate Cholecystitis

  • 1-2 g intravenously (IV) every 8 hours for 4-7 days

Uncomplicated Urinary Tract Infection

  • 1 g intravenously (IV) every 12 hours

Preparation for Surgery

There are no dosing recommendations for pediatric patients for perioperative prophylaxis or for pediatric patients with renal impairment

Medically Reviewed by a Doctor on 8/15/2017

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