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Chlorpheniramine

Medical and Pharmacy Editor:

Brand Name: ChlorTrimeton, Diabetic Tussin

Generic Name: Chlorpheniramine

Drug Class: Antihistamines, 1st Generation

What Is Chlorpheniramine and How Does It Work?

Chlorpheniramine is an antihistamine used to treat sneezing, itching, watery eyes, and runny nose caused by allergies or the common cold.

Chlorpheniramine is available under the following different brand names: ChlorTrimeton, and Diabetic Tussin.

Dosages of Chlorpheniramine:

Adult and Pediatric Dosage Forms and Strengths

Tablet

  • 4 mg
  • 8 mg
  • 12 mg

Syrup

  • 2 mcg/5 mL

Suspension (pediatric only)

  • 2 mg/mL

Dosage Considerations – Should be Given as Follows:

Allergic Rhinitis

Adult:

  • Tablets or syrup: 4 mg orally every 4-6 hours; not to exceed 24 mg/day
  • Extended-release tablets: 8 mg orally every 8-12 hours or 12 mg every 12 hours; not to exceed 24 mg/day
  • Extended-release capsules: 12 mg orally once/day; not to exceed 24 mg/day
  • Sustained-release capsules: 8-12 mg orally every 8-12 hours, up to 16-24 mg/day

Pediatric:

  • Children under 2 years: Safety and efficacy not established
  • Children 2-6 years: 1 mg orally every 4-6 hours; not to exceed 6 mg/day
  • Children 6-12 years: 2 mg orally every 4-6 hours; not to exceed 12 mg/day or sustained release at bedtime
  • Children over 12 years:
    • Tablets or syrup: 4 mg orally every 4-6 hours; not to exceed 24 mg/day
    • Extended-release tablets: 8 mg orally every 8-12 hours or 12 mg every 12 hours; not to exceed 24 mg/day
    • Extended-release capsules: 12 mg orally once/day; not to exceed 24 mg/day
    • Sustained-release capsules: 8-12 mg orally every 8-12 hours, up to 16-24 mg/day

Geriatric:

Additional Information

Other Indications and Uses

What Are Side Effects Associated with Using Chlorpheniramine?

Common side effects of chlorpheniramine include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Chlorpheniramine?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Chlorpheniramine has no known severe interactions with other drugs.

Serious interactions of chlorpheniramine include:

  • eluxadoline
  • idelalisib
  • isocarboxazid
  • ivacaftor
  • sodium oxybate
  • tranylcypromine

Chlorpheniramine has moderate interactions with at least 201 different drugs.

Mild interactions of chlorpheniramine include:

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

What Are Warnings and Precautions for Chlorpheniramine?

Warnings

This medication contains chlorpheniramine. Do not take ChlorTrimeton or Diabetic Tussin if you are allergic to chlorpheniramine or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

Effects of Drug Abuse

  • None

Short-Term Effects

  • See "What Are Side Effects Associated with Using Chlorpheniramine?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Chlorpheniramine?"

Cautions

Pregnancy and Lactation

  • Use chlorpheniramine with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • Chlorpheniramine's excretion in milk is unknown. It is not recommended for use while breastfeeding.
Reviewed on 8/15/2017

Medscape. Chlorpheniramine.
https://reference.medscape.com/drug/chlortrimeton-chlorpheniramine-343386
RxList. ChlorTrimeton Side Effects Drug Center.
https://www.rxlist.com/chlor-trimeton-side-effects-drug-center.htm

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