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Cilostazol

Medical and Pharmacy Editor:

Brand Name: Pletal

Generic Name: cilostazol

Drug Class: Antiplatelet Agents, Hematologic; PDE-3 Inhibitors; Phospholipase A2 Inhibitors

What Is Cilostazol and How Does It Work?

Cilostazol is a quinolinone derivative used for treatment of intermittent claudication and peripheral vascular disease.

Cilostazol is available under the following different brand names: Pletal.

Dosages of Cilostazol:

Dosage Forms and Strengths

Tablet

  • 59 mg
  • 100 mg

Dosage Considerations – Should be Given as Follows:

Peripheral Vascular Disease

Postmenopausal women

  • 100 mg orally every 12 hours 30 minutes before or 2 hours after meals

Dosing considerations

  • CYP2C19 or CYP3A4 inhibitors: Reduce dosage to 50 mg orally every 12 hours

Thrombotic Complications of Coronary Angioplasty (Off-label)

  • 100 mg every 12 hours 30 minutes before or 2 hours after meals

Renal Impairment

  • CrCl less than 25 mL/min: Use caution

Hepatic Impairment

  • Moderate to severe: Use caution

Pediatric

  • Safety and efficacy not established
Medically Reviewed by a Doctor on 5/1/2017



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