Naphazoline/Zinc Sulfate/Glycerin Ophthalmic

Reviewed on 9/13/2021

What Is Naphazoline/Zinc Sulfate/Glycerin Ophthalmic and How Does It Work?

Naphazoline/zinc sulfate/glycerin ophthalmic is an over-the-counter (OTC) product used for temporary relief of ocular (eye) redness caused by irritation and relief of burning or irritation caused by dry eyes.

Naphazoline/zinc sulfate/glycerin ophthalmic is available under the following different brand names: Clear Eyes Cooling Comfort Itchy Eye Relief.

What Are the Dosages of Naphazoline/Zinc Sulfate/Glycerin Ophthalmic?

Dosages of Naphazoline/Zinc Sulfate/Glycerin Ophthalmic:

Dosage Forms and Strengths

Ophthalmic Solution

  • 0.012%/0.25%/0.25%

Dosage Considerations – Should be Given as Follows:

Ocular Vasoconstrictor/Decongestant

  • Temporary relief of ocular redness caused by irritation and relief of burning or irritation caused by dry eyes
  • 1-2 drops to the affected eye every 3-4 hours up to four times daily as needed
  • Not to exceed 72 hours of use

What Are Side Effects Associated with Using Naphazoline/Zinc Sulfate/Glycerin Ophthalmic?

Side effects of naphazoline/zinc sulfate/glycerin ophthalmic include:

  • Blurred vision
  • Mild temporary stinging and/or irritation
  • Dilated pupils
  • Increased or decreased intraocular pressure
  • Headache

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Naphazoline/Zinc Sulfate/Glycerin Ophthalmic?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Naphazoline/zinc sulfate/glycerin ophthalmic has no listed severe interactions with other drugs.
  • Naphazoline/zinc sulfate/glycerin ophthalmic has no listed serious interactions with other drugs.
  • Naphazoline/zinc sulfate/glycerin ophthalmic has no listed moderate interactions with other drugs.
  • Naphazoline/zinc sulfate/glycerin ophthalmic has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

SLIDESHOW

Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow

What Are Warnings and Precautions for Naphazoline/Zinc Sulfate/Glycerin Ophthalmic? 

Warnings

  • This medication contains naphazoline/zinc sulfate/glycerin ophthalmic. Do not take Clear Eyes Cooling Comfort Itchy Eye Relief if you are allergic to naphazoline/zinc sulfate/glycerin ophthalmic or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Do not use with monoamine oxidase inhibitors (MAOIs)
  • Narrow-angle glaucoma
  • Hypersensitivity
  • Stop use if vision changes, eye pain, the condition worsens

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Naphazoline/Zinc Sulfate/Glycerin Ophthalmic?”

Long-Term Effects

  • See "What Are Side Effects Associated with Using Naphazoline/Zinc Sulfate/Glycerin Ophthalmic?”

Cautions

  • Use with caution in patients with hypertension, cardiovascular abnormalities, diabetes mellitus, hyperthyroidism, infection, or injury
  • Rare reports of hypertension, cardiac irregularities, nervousness, nausea, dizziness, weakness, and sweating

Pregnancy and Lactation

  • Use naphazoline/zinc sulfate/glycerin ophthalmic with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • It is unknown if naphazoline/zinc sulfate/glycerin ophthalmic is distributed in milk.
  • Pregnant or breastfeeding patients should seek the advice of a health professional before using over-the-counter (OTC) drugs.
References
https://reference.medscape.com/drug/clear-eyes-cooling-comfort-itchy-eye-relief-naphazoline-zinc-sulfate-glycerin-ophthalmic-999728

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