Reviewed on 8/12/2021

What Is Cortisone and How Does It Work?

Cortisone is a prescription drug and is a corticosteroid hormone (glucocorticoid). It decreases your body's natural defensive response and reduces symptoms such as swelling and allergic-type reactions.

Cortisone is used to treat conditions such as arthritis, blood/hormone/immune system disorders, allergic reactions, certain skin and eye conditions, breathing problems, and certain cancers.

Dosage of Cortisone

Adult and Pediatric Dosages:


  • 5 mg
  • 10 mg
  • 25 mg

Dosing Considerations – Should be Given as Follows:



  • 2.5 mg/kg/day orally divided every 8 hours or 25-300 mg/day orally each day or divided every 12 hours
  • 1-5 mg/kg intramuscularly each day


  • 2.5 mg-10 mg/kg/day orally or 20-300 mg/m2/day orally divided every 6-8 hours

Physiologic Replacement


  • 0.5-0.75 mg/kg/day orally divided every 8 hours or 25-35 mg/day
  • 0.25-0.35 mg/kg intramuscularly each day


  • 0.5-0.75 mg/kg/day orally or 20-25 mg/sq.meter/day orally divided every 8 hours


Could I Be Allergic? Discover Your Allergy Triggers See Slideshow

What Are Side Effects Associated with Using Cortisone?

Common Side effects of Cortisone include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Cortisone?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Cortisone has no known severe interactions with other drugs.

Serious interactions of cortisone include:

Cortisone has serious interactions with at least 73 different drugs.

Cortisone has moderate interactions with at least 232 different drugs.

Cortisone has minor interactions with at least 121 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

What Are Warnings and Precautions for Cortisone?


  • This medication contains cortisone. Do not take it if you are allergic to cortisone or any ingredients contained in this drug.
  • Keep out of reach of children
  • In case of overdose, get medical help or contact a Poison Control Center immediately


  • Documented hypersensitivity
  • Systemic fungal infection

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Cortisone?"

Long-Term Effects

  • Risk of osteoporosis, myopathy, delayed wound healing
  • See "What Are Side Effects Associated with Using Cortisone?"


Pregnancy and Lactation

  • No information is available for use of cortisone during pregnancy
  • Consult your physician
  • Cortisone excretion in milk is unknown; use with caution when breastfeeding


Allergies can best be described as: See Answer
Medscape. Cortisone.
RxList. Cortone.

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