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Etodolac

Medical and Pharmacy Editor:

Brand Name: Lodine

Generic Name: Etodolac

Drug Class: NSAIDs

What Is Etodolac and How Does It Work?

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis, rheumatoid arthritis, and acute pain.

Etodolac is available under the following different brand names: Lodine.

Dosages of Etodolac:

Dosage Forms and Strengths

Tablet (adult only)

  • 400 mg
  • 500 mg

Capsule (adult only)

  • 200 mg
  • 300 mg

Tablet, extended-release (adult and pediatric)

  • 400 mg
  • 500 mg
  • 600 mg

Dosage Considerations – Should be Given as Follows:

Pain

  • Immediate release: 200-400 mg orally every 6-8 hours; not to exceed 1000 mg/day (not evaluated)

Osteoarthritis

  • Immediate release: 600-1000 mg/day orally divided every 8-12 hours or 900 mg/day orally divided every 8 hours; doses greater than 1000 mg/day not evaluated
  • Extended release: 400-1000 mg orally once daily; not to exceed 1200 mg/day (not evaluated)

Rheumatoid Arthritis

  • Immediate release: 600-1000 mg/day orally divided every 8-12 hours or 900 mg/day orally divided every 8 hours; doses greater than 1000 mg/day not evaluated
  • Extended release: 400-1000 mg orally once daily; not to exceed 1200 mg/day (not evaluated)

Juvenile Rheumatoid Arthritis

Children under 6 years

  • Safety and efficacy not established

Children 6-16 years

  • 20-30 kg (extended release): 400 mg orally once daily
  • 31-45 kg (extended release): 600 mg orally once daily
  • 46-60 kg (extended release): 800 mg orally once daily
  • Over 60 kg (extended release): 1000 mg orally once daily

Dosing considerations

  • Safety and effectiveness of conventional tablets for juvenile rheumatoid arthritis not established

Dosing Considerations

  • Take with food or 8-12 oz of water to avoid gastrointestinal (GI) effects
  • Less than 60 kg: Not to exceed 20 mg/kg orally
  • Mild-to-moderate renal impairment: Dose adjustment not necessary
  • Severe renal impairment; Not recommended
  • Hepatic impairment: Dose adjustment not necessary

What Are Side Effects Associated with Using Etodolac?

Common side effects of etodolac include:

Less common side effects of etodolac include:

Serious side effects of of etodolac include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Etodolac?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Etodolac has no known severe interactions with other drugs.

Serious interactions of etodolac include:

Etodolac has moderate interactions with at least 227 different drugs.

Etodolac has mild interactions with at least 79 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

What Are Warnings and Precautions for Etodolac?

Warnings

Cardiovascular risk:

Gastrointestinal risk:

  • NSAIDs increase risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and gastric or intestinal perforation, which can be fatal
  • GI adverse events may occur at any time during use and without warning symptoms
  • Elderly patients are at greater risk for serious GI events

This medication contains etodolac. Do not take Lodine if you are allergic to etodolac or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

Absolute

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Etodolac?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Etodolac?"

Cautions

Pregnancy and Lactation

  • Use etodolac with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done. Avoid use of etodolac in late pregnancy (may cause premature closure of ductus arteriosus).
  • Quebec Pregnancy Registry identified 4705 women who had a spontaneous abortion by 20 weeks' gestation; each case was matched to 10 control subjects (n=47,050) who had not had a spontaneous abortion; exposure to non-aspirin NSAIDs during pregnancy was documented in approximately 7.5% of cases of spontaneous abortion and approximately 2.6% of controls.
  • It is unknown whether etodolac is excreted in breast milk; it is not recommended for use while breastfeeding.
Reviewed on 8/22/2017

Medscape. Etodolac.
https://reference.medscape.com/drug/lodine-etodolac-343286
RxList. Lodine Side Effects Center.
https://www.rxlist.com/lodine-side-effects-drug-center.htm

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