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Ezetimibe

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Brand Name: Grifulvin V, Gris-PEG

Generic Name: Ezetimibe

Drug Class: Antifungals, Systemic

What Is Ezetimibe and How Does It Work?

Ezetimibe is a prescription drug used as therapy with lipid altering agents and should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. Drug therapy is indicated as an adjunct to diet when the response to a diet restricted in saturated fat and cholesterol and other nonpharmacologic measures along has been inadequate.

Ezetimibe is available under the following different brand names: Zetia.

Dosages of Ezetimibe:

Adult and Pediatric Dosages:

Tablets

Dosage Considerations – Should be Given as Follows:

Hypercholesterolemia

Adult Dosage:

  • 10 mg orally each day

Pediatric:

  • Children under 10 years: safety and efficacy not established
  • Children over 10 years: 10 mg orally each day

Dosing Considerations

  • Overdose management: Treatment should be supportive

Dosing Modifications

Renal impairment

  • Monotherapy: No dosage adjustment required
  • Moderate to severe: Renal impairment is a risk factor for statin-associated myopathy; caution when coadministered with doses of simvastatin exceeding 20 mg

Hepatic impairment

  • Mild (Child-Pugh class A): Dose adjustment not necessary
  • Moderate to severe (Child-Pugh class B or C): Not recommended

What Are Side Effects Associated with Using Ezetimibe?

Common side effects of ezetimibe include:

Postmarketing side effects of ezetimibe include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Ezetimibe?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Ezetimibe has no known severe interactions with other drugs.

Serious interactions of ezetimibe include:

Moderate interactions of ezetimibe include:

  • cholestyramine
  • sofosbuvir/velpatasvir

Minor interactions of ezetimibe include:

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

What Are Warnings and Precautions for Ezetimibe?

Warnings

This medication contains ezetimibe. Do not take Zetia if you are allergic to ezetimibe or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Hypersensitivity

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Ezetimibe?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Ezetimibe?"

Cautions

  • Use caution in patients with mild hepatic impairment or severe renal impairment
  • Cholelithiasis reported (when coadministered with fibric acid derivatives)
  • Rule out secondary causes of hyperlipidemia prior to therapy

Pregnancy and Lactation

  • Use ezetimibe with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done
  • It is unknown if ezetimibe is excreted into breast milk; use with caution if breastfeeding. Consult your physician.
  • Pregnant or breastfeeding women should seek advice of a health professional before using over-the-counter drugs
Reviewed on 7/26/2017

Medscape. Ezetimibe.
https://reference.medscape.com/drug/zetia-ezetimibe-342454#0
RxList. Zetia Monograph.
https://www.rxlist.com/zetia-drug.htm

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