Brand Name: Tambocor
Generic Name: Flecainide
Drug Class: Antidysrhythmics, lc
What Is Flecainide and How Does It Work?
Flecainide is a prescription medication used to treat paroxysmal supraventricular tachycardias (PSVT), including atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia and other supraventricular tachycardias of unspecified mechanism associated with disabling symptoms, paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms and documented ventricular arrhythmias, such as sustained ventricular tachycardia (sustained VT), that in the judgment of the physician are life-threatening.
Flecainide is available under the following different brand names: Tambocor.
Dosage of Flecainide:
Adult and Pediatric Dosages
- 50 mg
- 100 mg
- 150 mg
Dosage Considerations – Should be Given as Follows:
- PSVT and paroxysmal atrial fibrillation
- 50 mg orally twice daily; may increase by 50 mg every 4 days; do not exceed 300 mg/day
- Sustained VT
- 100 mg orally twice daily initiated in hospital; may increase by 50 mg every 4 days; do not exceed 400 mg/day
- Infants under 6 months: 50 mg/m²/day orally divided every 8-12 hours
- Infants 6 months or older: 100 mg/m²/day orally divided every 8-12 hours
- Not to exceed 200 mg/m²/day
Adults and Pediatric Dosages:
- Pediatric only: Usual therapeutic level: 200-500 ng/ml; some may require under 800 ng/ml for adequate control
- Steady-state plasma levels not achieved for 3-5 days, so increases in dosage should not be made less than every 4 days
- Loading dose not recommended, due to increased incidence of proarrhythmic events and chronic heart failure
- Patients intolerant to twice daily dosing may require 8 hour dosing
- Once adequate control of arrhythmia has been achieved, may reduce dose, provided there is no loss of efficacy
- After 5 doses/steady state, obtain ECG after initiation or change of dose; obtain plasma trough flecainide levels 1 hour pre-dose
- Usual trough plasma levels: 0.2-1 mcg/mL
- When given concomitantly with amiodarone, reduce flecainide dose by 50% and monitor closely
- Dose cautiously in patients with history of heart attach (myocardial infarction) or chronic heart failure
- When switching from another antiarrhythmic to flecainide, allow over 2-4 plasma half-lives to elapse before starting flecainide; if discontinuation of previous drug may produce life-threatening arrhythmias, consider hospitalizing patient
Adult and Pediatric Dosages:
- Severe (under 35 ml/min): 100 mg orally once daily or 50 mg orally twice daily
- Higher than 25 ml/min: 100 mg orally twice daily
- Use only if benefits outweigh risk; monitor plasma levels regularly; reduce dose as necessary
What Are Side Effects Associated with Using Flecainide?
Side effects of flecainide include:
- visual disturbances
- irregular heartbeat (arrhythmias)
- strong or irregular heartbeat (palpitations)
- shakiness (tremors)
- chest pain
- shortness of breath
- abdominal pain
- fast heart rate
- heart stops beating (sinus pause/arrest)
- stomach pain
- lack of appetite
- double vision
- reduced sense of touch
- numbness and tingling
- muscular weakness
- loss of full control of bodily movements
- spinning sensation (vertigo)
- ringing in the ears (tinnitus)
- difficulty falling asleep
- swollen lips, tongue, and mouth
- sudden difficulty breathing
- muscle pain
- severe chest pain
- atrioventricular bloc (AV block)
- slow heart rate
- high blood pressure (hypertension)
- low blood pressure (hypotension)
- gas (flatulence)
- excessive urination
- urinary retention
- low white blood cell count
- decreased white blood cell count
- low blood platelet count
- redness and peeling of the skin
- hair loss
- eye pain/irritation
- sun sensitivity
- rapid, involuntary eye movement
- change in taste
- dry mouth
- speech disorder
- near-unconsciousness (stupor)
- nerve pain
- pneumonitis/pulmonary infiltration
- decreased sex drive (libido)
- morbid dreams
- lack of interest
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
What Other Drugs Interact with Flecainide?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Severe interactions of flecainide include:
Flecainide has serious interactions with at least 29 different drugs.
Flecainide has moderate interactions with at least 128 different drugs.
Mild interactions of flecainide include:
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
What Are Warnings and Precautions for Flecainide?
- National Heart, Lung, and Blood Institute (NHLBI) Cardiac Arrhythmia Suppression Trial (CAST): Excessive mortality or nonfatal cardiac arrest (7.7%) shown with encainide or flecainide, compared with placebo (3%)
- This was a long-term, multicenter, randomized, double-blind study in patients with asymptomatic, non-life-threatening ventricular arrhythmias who previously had heart attack (myocardial infarction) over 6 days prior but less than
- Average duration of treatment with encainide or flecainide was 10 months
- Applicability of results to other populations is uncertain
- Reserve class IC antiarrhythmics use for life-threatening ventricular arrhythmias only
- Due to known proarrhythmic properties of flecainide and lack of evidence of improved survival for any antiarrhythmics, flecainide use should be restricted to patients with life-threatening ventricular arrhythmias
Ventricular proarrhythmic effects with atrial flutter
- Not recommended for chronic atrial fibrillation
- 10.5% incidence of ventricular tachycardia/fibrillation in patients treated for chronic atrial fibrillation
- Proarrhythmic effects with flecainide for atrial fibrillation/flutter: Increased risk of PVCs, ventricular tachycardia, ventricular fibrillation, and fatality
- As with other class I agents, use of flecainide for atrial flutter has been reported with 1:1 atrioventricular conduction due to atrial rate slowing
- Paradoxical increase in ventricular rate may occur in patients with atrial fibrillation; concomitant negative chronotropic therapy (digoxin, beta blockers) may lower risk
- This medication contains flecainide. Do not take Tambocor if you are allergic to flecainide or any ingredients contained in this drug.
- Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately
- 2nd or 3rd degree atrioventricular block, right bundle branch block when associated with left hemiblock (bifascicular block), unless pacemaker is present to sustain cardiac rhythm; discontinue therapy immediately
Effects of Drug Abuse
- No information available
- See "What Are Side Effects Associated with Using Flecainide?"
- See "What Are Side Effects Associated with Using Flecainide?"
- Atrial fibrillation, chronic heart failure, low blood pressure, high blood pressure, post heart attack (myocardial infarction) patients, geriatrics, proarrhythmia events, liver/kidney impairment, sick sinus syndrome
- May slow cardiac conduction to produce dose-related increases in PR, QRS, and QT intervals; manage patient on lowest effective dose
- Discontinuation should be done in hospital
- Causes increased mortality in post-acute myocardial infarction (AMI) period, also with chronic atrial fibrillation
- May affect endocardial pacemaker reversibly by increasing endocardial pacing thresholds or suppressing ventricular escape rhythms; do not administer to patients with existing poor thresholds or nonprogrammable pacemakers unless suitable pacing rescue is available
- Correct preexisting low potassium or high potassium before initiating therapy
- May cause visual disturbances
- Flecainide may depress LV systolic function significantly with preexisting LV systolic dysfunction
- Flecainide should be avoided in patients with heart failure or structural heart disease
RxList. Tambocor Monograph.