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Glyburide

Medical and Pharmacy Editor:

Brand Name: Diabeta, Glynase, Glynase PresTab

Generic Name: Glyburide

Drug Class: Antidiabetics, Sulfonylureas

What Is Glyburide and How Does It Work?

Glyburide is a diabetes medicine used to help control blood sugar levels and treat type 2 diabetes.

Glyburide is available under the following different brand names: Diabeta, Glynase, and Glynase PresTab.

Dosage of Glyburide:

Dosage Forms and Strengths

  • 1.25 mg
  • 2.5 mg
  • 5 mg

Tablet, micronized

  • 1.5 mg
  • 3 mg
  • 5 mg
  • 6 mg

Dosing Consideraations – Should be Given as Follows:

Type 2 Diabetes Mellitus

Regular tablets

  • Initial: 2.5-5 mg orally once/day
  • Maintenance: 1.25-20 mg orally once/day or every 12 hours
  • Not to exceed 20 mg/day
  • Consider administering every 12 hours for doses greater than 10 mg/day

Micronized tablets

  • Initial: 1.5-3 mg orally once/day
  • Maintenance: 0.75-12 mg orally once/day
  • Not to exceed 12 mg/day
  • Patients at risk for hypoglycemia: 0.75 mg orally once/day initially

Transferring from insulin therapy to glyburide

  • Current insulin dose less than 20 units: Discontinue insulin and initiate glyburide dose at 2.5-5 mg/day (regular) or 1.5-3 mg/day (micronized)
  • Current insulin dose 20-40 units: Discontinue insulin and initiate glyburide dose at 5 mg/day (regular) or 3 mg/day (micronized)
  • Current insulin dose more than 40 units: Decrease insulin dose by 50% and initiate glyburide dose at 5 mg/day (regular) or 3 mg/day (micronized); increase glyburide dose by 1.25-2.5 mg (regular) or 0.75-1.5 mg/day (micronized); decrease insulin dose gradually, based on patient's response as glyburide dose increased

Geriatric

  • Initial: 1.25 mg/day if non-micronized tablets or 0.75 mg/day of micronized tablets
  • Depending on glucose response, may increase dose by no more than 1.25-2.5 mg (regular) or 0.75-1.5 mg (micronized) every week
  • May administer maintenance dose of 1.25-20 mg/day (regular) or 0.75-12 mg/day (micronized); for better satisfactory response may divide dose every 12 hours for patients taking greater than 10 mg/day (regular) or greater than 6 mg/day (micronized)

Dosage Modifications

  • Renal impairment: If CrCl less than 50 mL/min; caution advised
  • Hepatic impairment: Use conservative initial and maintenance doses; avoid use in severe liver disease
  • Pediatric: Safety and efficacy not established

Dosing considerations, geriatric

  • Because the elderly are susceptible to the hypoglycemic effects of glucose-lowering drugs, the question of how tightly glucose levels should be controlled is controversial
  • Recognizing hypoglycemia in the elderly may be challenging
  • Monitoring other parameters associated with cardiovascular disease, such as blood pressure and cholesterol, may be more important than normalized glycemic control
  • Initial and maintenance dosing should be conservative
  • Use caution in patients with renal insufficiency
Medically Reviewed by a Doctor on 6/2/2017



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