Reviewed on 9/10/2021

What Is Glycerin and How Does It Work?

Glycerin is used for relief of occasional constipation.

What Are Dosages of Glycerin?

Dosages of Glycerin:

Adult and Pediatric Dosage Forms and Strengths

  • 1 g
  • 1.5 g
  • 2 g
  • 2.1 g
  • 2.8 g

Dosage Considerations – Should be Given as Follows:



  • 2-2.8 g suppository, retain 15 minutes, as needed constipation

Children 2-6 years

  • 1-1.7 g suppository, retain 15 minutes, as needed constipation

Children over 6 years

  • 2-8 g suppository, retain 15 minutes, as needed constipation


  • The patient should lie on the left side with knees bent
  • Remove protective wrap before inserting
  • Gently insert the tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)
  • For liquid suppository, squeeze the bulb until all liquid is expelled and discard unit


Super Tips to Boost Digestive Health: Bloating, Constipation, and More See Slideshow

What Are Side Effects Associated with Using Glycerin?

Side effects associated with the use of Glycerin, include the following:

  • Excessive bowel activity
  • Cramping
  • Rectal irritation
  • Cramping rectal pain

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Glycerin ?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Glycerin has no known interactions with other drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine.

What Are Warnings and Precautions for Glycerin ?


  • This medication contains glycerin
  • Do not take glycerin if you are allergic to glycerin or any ingredients contained in this drug
  • Keep out of reach of children
  • In case of overdose, get medical help or contact a Poison Control Center immediately


  • GI obstruction, severe impaction

Effects of Drug Abuse

  • No information provided

Short-Term Effects

  • See "What Are Side Effects Associated with Using Glycerin?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Glycerin?"


  • Do not use when abdominal pain, nausea, or vomiting present (unless directed by physician)
  • Frequent or prolonged use of laxatives may result in independence
  • Rectal bleeding or failure to have bowel movement requires physician care
  • Contact a physician before use if experience a sudden change in bowel habits that last more than 2 weeks
  • Do not use for longer than 1 week

Pregnancy and Lactation

  • Data is not available about the use of glycerin during pregnancy. Consult your doctor
  • It is not known whether glycerin is excreted in breast milk; no risks have been shown to nursing infants
Medscape. Glycerin.
DailyMed. Glycerin.

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