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Hydroxyzine

Medical and Pharmacy Editor:

Brand Name: Vistaril

Generic Name: hydroxyzine

Drug Class: Antihistamines, 1st Generation; Antihistamines, Piperazine Derivatives; Antiemetic Agents

What Is Hydroxyzine and How Does It Work?

Hydroxyzine is used for the short-term treatment of nervousness and tension that may occur with certain mental/mood disorders (e.g., anxiety, dementia). It is also used to help manage withdrawal symptoms (e.g., anxiety, agitation) in alcoholics.

Other uses include helping to decrease anxiety and nausea before/after surgery or during childbirth or helping certain narcotic pain relievers (e.g., meperidine) work better.

Hydroxyzine belongs to a class of medications called antihistamines. It is thought to work by affecting certain natural substances (acetylcholine, serotonin) in your body or by acting directly on certain parts of the brain.

Hydroxyzine also blocks a natural substance that your body makes during an allergic reaction (histamine).

Hydroxyzine is available under the following different brand names: Vistaril.

Dosages of Hydroxyzine:

Adult Dosage Forms and Strengths

Tablet

  • 5 mg
  • 25 mg
  • 50 mg

Capsule

  • 25 mg
  • 50 mg
  • 100 mg

Syrup/oral suspension

  • 10 mg/5mL

Injectable solution

  • 25 mg/5mL
  • 50 mg/5mL

Dosage Considerations – Should be Given as Follows:

Anxiety

  • Symptomatic relief of anxiety associated with psychoneurosis and as adjunct in organic disease states
  • 50-100 mg orally divided every 6 hours or 50-100 mg intramuscularly (IM) divided every 4-6 hours
  • Younger than 6 years old: 50 mg/day orally divided every 6 hours
  • Children 6 years of age and older: 50-100 mg/day orally divided every 6 hours
  • Geriatric: 50-100 mg orally divided every 6 hours or 50-100 mg IM divided every 4-6 hours
  • Dosing considerations
    • Continuation of therapy for more than 4 months has not been studied; reassess need for therapy periodically

Pruritus (Itching)

  • Management of pruritus due to chronic hives (urticaria), contact dermatoses, and histamine-mediated pruritus
  • 25 mg oral/intramuscular (IM) divided every 6-8 hours
  • Younger than 6 years old: 50 mg/day orally divided every 6 hours
  • Children 6 years of age and older: 50-100 mg/day orally divided every 6 hours
  • Geriatric: 25 mg oral/IM every 6-8 hours; increased to 25 mg every 6-8 hours

Preoperative Sedation

  • Adult: 50-100 mg orally or 25-100 mg intramuscularly (IM)
  • Pediatric: 0.6 mg/kg orally, or 0.5-1.1 mg/kg IM
  • Dosing considerations
    • If treatment is initiated IM, subsequent doses may be administered orally

Dose Modification

Renal Impairment

  • Greater than 50 mL/min: Dose adjustment not necessary
  • 50 mL/min or more: Administer 50% normal dose

Hepatic Impairment

Geriatric

  • Advanced age associated with reduced drug clearance and with greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity; start at low end of dosage range, and observe closely
Medically Reviewed by a Doctor on 4/14/2017



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