Brand Name: Nexcede
Generic Name: Ketoprofen
Drug Class: NSAIDs
What Is Ketoprofen and How Does It Work?
Ketoprofen is available under the following different brand names: Nexcede.
Dosages of Ketoprofen:
Adult and Pediatric Dosages:
- 50 mg
- 75 mg
Capsules, extended release
- 200 mg
- 12.5 mg (OTC)
Dosage Considerations – Should be Given as Follows:
- Immediate-release: 25-50 mg orally every 6-8 hours as necessary
- Extended-release: 200 mg orally each day; not recommended for acute pain
- Initial: 25-50 mg orally every 6-8 hours; increase to 150-300 mg/day; not to exceed 300 mg
Rheumatoid Arthritis or Osteoarthritis
- Immediate-release: 75 mg orally every 8 hours or 50 mg orally every 6 hours
- Extended-release: 200 mg orally each day
- Immediate-release: 25-50 mg every 6-8 hours as needed
- Extended-release: Not recommended for acute pain
Other Indications and uses
- Off-label: vascular headache
- Safety and efficacy not established
What Are Side Effects Associated with Using Ketoprofen?
Common side effects of ketoprofen include:
- abdominal pain
- abnormal heart rhythm
- abnormal retention of lipids
- acute, inflammatory skin eruptions
- airway obstruction
- severe allergic reaction (anaphylaxis)
- alteration of taste
- bleeding in the eye
- blood circulation disorder
- blood in the stool
- blood in urine
- blood poisoning (septicemia)
- burping, belching
- changes in sex drive
- congestive heart failure
- coughing up blood
- dark sticky feces
- decreased bile flow
- decreased blood pressure
- deficient blood coagulation
- destruction of red blood cells
- diabetes mellitus (aggravated)
- difficult breathing
- difficulty sleeping
- dry eye
- dry mouth
- enlarged breasts in men
- eye pain
- facial swelling
- fast heart beat
- feeling unwell (malaise)
- gas (flatulence)
- gastrointestinal bleeding
- gastrointestinal perforation
- hair loss
- hay fever
- hearing impairment
- heart attack (myocardial infarction)
- high blood pressure (hypertension)
- immune hypersensitivity reaction
- impaired kidney function disorder
- inability to achieve an erection or orgasm (impotence)
- increased appetite
- increased liver function test
- inflamed and sore mouth
- inflammation of the large intestine
- inflammation within the kidney
- irritation of the stomach
- ketoprofen-induced stomach ulcer
- kidney disorder
- kidney failure
- light sensitivity
- liver failure
- loss of a nail from the nail bed
- loss of appetite
- low blood platelet count
- low blood sodium level
- low white blood cell count
- mouth ulcers
- muscle pain
- nose bleed
- personality disorder
- pigmentation change
- pink eye (conjunctivitis)
- pins and needles
- prolonged and excessive menstrual bleedings
- rectal bleeding
- red or purple rash
- redness and peeling of the skin
- ringing in the ears (tinnitus)
- scaling eczema
- severe allergic reaction (anaphylactic reaction)
- severe itching
- skin discoloration
- sore throat
- spinning sensation (vertigo)
- feeling uneasy
- Stevens-Johnson syndrome
- stroke (cerebrovascular accident)
- sudden difficulty to breathe
- swelling in arms and legs
- swelling in the kidney
- toxic epidermal necrolysis (TEN)
- viral meningitis
- visual disturbance
- vomiting blood
- weight gain
- weight loss
- yellowing of eyes and skin (jaundice)
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
What Other Drugs Interact with Ketoprofen?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Ketoprofen has no known severe interactions with other drugs.
Serious interactions of ketoprofen include:
- ketorolac intranasal
Ketoprofen has moderate interactions with 228 different drugs.
Ketoprofen has minor interactions with 79 different drugs.
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
What Are Warnings and Precautions for Ketoprofen?
Risk may increase with duration of use.
Patients with risk factors for or existing cardiovascular disease may be at greater risk.
NSAIDs increase risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Gastrointestinal adverse events may occur at any time during use and without warning symptoms.
Elderly patients are at greater risk for serious gastrointestinal events.
This medication contains ketoprofen. Do not take Nexcede if you are allergic to ketoprofen or any ingredients contained in this drug.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
- Absolute: ASA allergy
- Relative: Bleeding disorders, hepatic disease, peptic ulcer, stomatitis, ulcerative colitis, upper gastrointestinal disease, and late pregnancy (may cause premature closure of the ductus arteriosus).
Effects of Drug Abuse
- No information available
- See "What Are Side Effects Associated with Using Ketoprofen?"
- See "What Are Side Effects Associated with Using Ketoprofen?"
- Use caution in asthma (bronchial), cardiac disease, chronic heart failure, hypertension, renal impairment, and systemic lupus erythematosus (SLE).
- Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include the elderly, or those with impaired renal function, hypovolemia, heart failure, liver dysfunction, salt depletion, and individuals taking diuretics, ACE inhibitors, or angiotensin receptor blockers (ARBs).
- Heart Failure (HF) risks.
- NSAIDs have the potential to trigger heart failure by prostaglandin inhibition that leads to sodium and water retention, increased systemic vascular resistance, and blunted response to diuretics.
- NSAIDS should be avoided or withdrawn whenever possible.
- American Heart Association (AHA)/American College of Cardiology (ACC) Heart Failure Guidelines; Circulation. 2016; 134.
Pregnancy and Lactation
- Use of ketoprofen may be acceptable during pregnancy. Either animal studies show no risk or human studies are not available or animal studies showed minor risk and human studies were done and showed no risk. Use ketoprofen late in pregnancy only in in LIFE-THREATENING emergencies when no safer drug is available. Positive evidence of human fetal risk: premature closure of ductus arteriosus closure.
- The Quebec Pregnancy Registry identified 4705 women who had spontaneous abortions by 20 weeks' gestation; each case was matched to 10 control subjects (n=47,050) who had not had spontaneous abortions; exposure to nonaspirin NSAIDs during pregnancy was documented in approximately 7.5% of cases of spontaneous abortions and in approximately 2.6% of controls. (CMAJ, September 6, 2011; DOI:10.1503/cmaj.110454).
- It is unknown whether ketoprofen is excreted in breast milk. It is not recommended if breastfeeding.
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