Acetohydroxamic Acid

Reviewed on 8/23/2021

Brand Name and Other Names: Lithostat

Generic Name: Acetohydroxamic Acid

Drug Class: Antimicrobials, Adjunct

What Is Acetohydroxamic Acid Used For and How Does it Work?

Acetohydroxamic acid is used for chronic urinary tract infection (UTI) caused by urea-splitting organisms.

Acetohydroxamic acid is available under the following different brand names: Lithostat.

What Are the Dosages of Acetohydroxamic Acid?

Dosages of Acetohydroxamic Acid:

Dosage Forms and Strengths

Tablet

  • 250mg

Dosage Considerations – Should be Given as Follows:

Chronic Urinary Tract Infection

  • Indicated for chronic UTIs caused by urea-splitting organisms
  • Adult, Initial: 12 mg/kg/day orally divided every 6-8 hours on an empty stomach
  • Adult, Maintenance: 250 mg orally every 6-8 hours; not to exceed 1.5 g/day
  • Pediatric, Initial: 10 mg/kg/day orally divided every 6-8 hours on empty stomach; titrate to patient response

Renal Impairment

  • SCr 1.8-2.5 mg/dL [159-221 micromoles/L]: Dose every 12 hours; not to exceed 1 g/day
  • SCr greater than 2.5 mg/dL [greater than 221 micromoles/L]: Not recommended

What Are Side Effects Associated with Using Acetohydroxamic Acid?

Side effects of Acetohydroxamic Acid include:

Less common side effects of acetohydroxamic acid include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

SLIDESHOW

Urinary Incontinence in Women: Types, Causes, and Treatments for Bladder Control See Slideshow

What Other Drugs Interact with Acetohydroxamic Acid?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Acetohydroxamic acid has no listed severe interactions with other drugs.
  • Acetohydroxamic acid has no listed serious interactions with other drugs.
  • Moderate interactions of acetohydroxamic acid include:
  • Mild interactions of acetohydroxamic acid include:

What Are Warnings and Precautions for Acetohydroxamic Acid?

Warnings

  • This medication contains acetohydroxamic acid. Do not take Lithostat if you are allergic to acetohydroxamic acid or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

Effects of Drug Abuse

  • No information is available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Acetohydroxamic Acid?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Acetohydroxamic Acid?"

Cautions

  • Always use with appropriate antimicrobial treatment
  • Potential teratogen

Pregnancy and Lactation

  • Do not use acetohydroxamic acid in pregnancy. The risks involved outweigh the potential benefits. Safer alternatives exist.
  • It is unknown if acetohydroxamic acid is excreted in breast milk unknown. Acetohydroxamic acid is not recommended for use while breastfeeding.
References
https://reference.medscape.com/drug/lithostat-acetohydroxamic-acid-342577

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