Slideshows Images Quizzes

Lovastatin

Medical Editor:

Brand Name: Mevacor, Altoprev

Generic Name: Lovastatin

Drug Class: Lipid-Lowering Agents, Statins; HMG-CoA Reductase Inhibitors

What Is Lovastatin Used For?

Lovastatin is a cholesterol-lowering medication called a statin prescribed to treat elevated blood cholesterol levels.

Lovastatin should be used in addition to dietary modifications as part of a treatment plan to lower cholesterol levels when the response to diet and other non-pharmacological measures alone have been inadequate to reduce cardiovascular risk.

Lovastatin is available under the following different brand names: Mevacor, and Altoprev.

Dosages of Lovastatin

Dosage Forms and Strengths

Tablets, extended-release

  • 10mg
  • 20mg
  • 40mg
  • 60mg

Tablets

  • 10mg
  • 20mg
  • 40mg

Dosage Considerations – Should be Given as Follows:

Hypercholesterolemia

Mevacor (immediate-release): 20 mg orally once/day with evening meal initially, or may divide daily dose twice daily; adjust dose at 4-week intervals if increase required; not to exceed 80 mg/day

Altoprev (extended-release): 10-60 mg orally at bedtime

Heterozygous Familial Hypercholesterolemia, Pediatric

Children 10-17 years: 20-40 mg orally once/day; not to exceed 40 mg/day

Initiate with 10 mg/day if patient requires smaller LDL-C reduction

 Dosing Considerations

Co-administration with danazol, diltiazem, or verapamil: Do not exceed 20 mg lovastatin daily

Co-administration with amiodarone: Do not exceed 40 mg lovastatin daily

Avoid large quantities of grapefruit juice (greater than 1 quart/day)

Overdose management

Adverse drug reactions from overdose may include peripheral neuropathy, diarrhea, increased potassium, myopathy, rhabdomyolysis, acute renal failure, elevated liver function tests, eye lens opacities Treatment is supportive

Dosing Modifications

Renal impairment (severe; CrCl less than 30 mL/minute): Doses greater than 20 mg/day should be carefully considered and, if deemed necessary, implemented cautiously

What Are Side Effects Associated with Using Lovastatin?

Common side effects of lovastatin include:

Less common side effects of lovastatin include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Lovastatin?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

 Lovastatin has severe/serious/moderate/mild interactions with at least 34 different drugs.

Lovastatin has severe/serious/moderate/mild interactions with at least 77 different drugs.

Lovastatin has severe/serious/moderate/mild interactions with at least 79 different drugs. Mild Interactions of lovastatin include:

 This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Lovastatin?

Warnings

This medication contains lovastatin. Do not take Mevacor or Altoprev if you are allergic to lovastatin or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

Hypersensitivity to lovastatin or other components

Active liver disease, or unexplained elevated transaminases

Pregnancy, lactation

Concomitant administration with strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, cobicistat, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin, and nefazodone)

Effects of Drug Abuse

No information available

Short-Term Effects
  • See "What Are Side Effects Associated with Using Lovastatin?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Lovastatin?"

Cautions

Non-serious and reversible cognitive side effects may occur.

Increased blood sugar and glycosylated hemoglobin (HbA1c) levels reported with statin intake.

Rhabdomyolysis, risk of myopathy: Risk increased by co-administration CYP3A4 inhibitors or other drugs that cause myopathy.

Avoid co-administration with cyclosporine or gemfibrozil; caution with other fibrates or lipid-lowering doses of niacin (1 g/day or more) because of increased risk for myopathy.

Heavy alcohol use, history of liver disease, renal failure.

Discontinue if markedly elevated creatine phosphokinase (CPK) levels occur or myopathy is diagnosed or suspected; also, temporarily withhold in any patient experiencing an acute or serious condition predisposing to the development of renal failure secondary to rhabdomyolysis (egg, sepsis; hypotension; major surgery; trauma; severe metabolic, endocrine, or electrolyte disorders; uncontrolled epilepsy).

Rare reports of immune-mediated necrotizing myopathy (IMNM), characterized by increased serum creatine kinase that persists despite discontinuation of statin.

Obtain baseline liver enzyme tests before initiating and then periodically thereafter.

Brand Altocor renamed Altoprev due to confusion with Advicor.

Pregnancy and Lactation

Do not use lovastatin in pregnancy. The risks involved outweigh potential benefits. Safer alternatives exist.

Lovastatin is contraindicated in lactation; it is unsafe for use while breastfeeding.

Reviewed on 1/26/2018

SOURCE:
https://reference.medscape.com/drug/mevacor-altoprev-lovastatin-342458
https://www.rxlist.com/mevacor-side-effects-drug-center.htm

Health Solutions From Our Sponsors