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Medical and Pharmacy Editor:

Brand Name: Osmitrol

Generic Name: Mannitol

Drug Class: Diuretics, Osmotic Agents

What Is Mannitol and How Does It Work?

Mannitol is a diuretic used to force urine production in people with acute (sudden) kidney failure. Mannitol injection is also used to reduce swelling and pressure inside the eye or around the brain.

Mannitol is available under the following different brand names: Osmitrol.

Dosages of Mannitol:

Adult and Pediatric Dosage Forms and Strengths


  • 5%
  • 10%
  • 15%
  • 20%
  • 25%

Dosage Considerations – Should be Given as Follows:

Cerebral Edema

Reduction of intracranial pressure and treatment of cerebral edema

1.5-2 g/kg intravenously (IV) infused over 30-60 minutes

Edema, Pediatric

  • 0.25-1 g/kg intravenously (IV) initially; maintenance dose of 0.25-0.5 g/kg IV every 4-6 hours

Intraocular Pressure

  • 1.5-2 g/kg intravenously (IV) infused over 30-60 minutes


  • Test dose: 200 mg/kg intravenously (IV) infused over 3-5 minutes
  • Load: 500-1000 mg/kg IV for 1 dose
  • Maintenance: 250-500 mg/kg IV every 4-6 hours
  • Pediatric: Test dose: 0.2 g/kg IV over 3-5 minutes; not to exceed 12.5 g
  • Discontinue if no diuresis within 2 hours

Other Information

  • Do NOT give simultaneously with blood
  • Use 15-25% solution
  • Pediatric: Treatment of intoxications: Give therapeutic dose as 5 or 10% solution intravenously (IV) as needed

Other Indications and Uses

  • Brain mass
Medically Reviewed by a Doctor on 9/6/2017

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