Slideshows Images Quizzes

Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. See additional information.

L-Methylfolate/Pyridoxal 5'-Phosphate/Methylcobalamin

Reviewed on 3/5/2020

Brand Name: Metanx
Generic Name: L-Methylfolate/Pyridoxal 5'-Phosphate/Methylcobalamin
Drug Class: Food, Supplements

What Is L-Methylfolate/Pyridoxal 5-Phosphate/Methylcobalamin and How Does It Work?

L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin is used as medical food for the clinical dietary management of endothelial dysfunction associated with diabetic peripheral neuropathy.

L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin is available under the following different brand names: Metanx.

Dosages of L-Methylfolate/Pyridoxal 5’-Phosphate/Methylcobalamin:

Dosage Forms and Strengths

Capsule

  • 3mg/35mg/2mg

Dosage Considerations – Should be Given as Follows:

Diabetic Peripheral Neuropathy

  • Medical food for the clinical dietary management of endothelial dysfunction associated with diabetic peripheral neuropathy
  • 1 capsule orally twice daily, or 2 capsules once daily
  • Safety and efficacy not established in pediatric patients

What Are Side Effects Associated with Using L-Methylfolate/Pyridoxal 5’-Phosphate/Methylcobalamin?

Side effects of L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with L-Methylfolate/Pyridoxal 5’-Phosphate/Methylcobalamin?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin has no listed severe interactions with other drugs.
  • L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin has no listed serious interactions with other drugs.
  • L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin has no listed moderate interactions with other drugs.
  • L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin has no listed mild interactions with other drugs.
     

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

SLIDESHOW

Type 2 Diabetes: Signs, Symptoms, Treatments See Slideshow

What Are Warnings and Precautions for L-Methylfolate/Pyridoxal 5’-Phosphate/Methylcobalamin?

Warnings
This medication contains L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin. Do not take Metanx if you are allergic to L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin or any ingredients contained in this drug.


Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Hypersensitivity to ingredients

Effects of Drug Abuse
No information available

Short-Term Effects

See "What Are Side Effects Associated with Using L-Methylfolate/Pyridoxal 5’-Phosphate/Methylcobalamin?”

Long-Term Effects

See "What Are Side Effects Associated with Using L-Methylfolate/Pyridoxal 5’-Phosphate/Methylcobalamin?”

Cautions

  • Contains milk, soy, and carmine
  • Daily folic acid administration (greater than 0.1 mg/day), may obscure detection of B12 deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B12 deficiency, including pernicious anemia, while not addressing the neurological manifestations); L-methylfolate may be less likely than folic acid to mask vitamin B12 deficiency

Pregnancy and Lactation

Use L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.

It is unknown whether L-methylfolate/pyridoxal 5’-phosphate/methylcobalamin is distributed in breast milk. Consult your doctor before breastfeeding.

References
https://reference.medscape.com/drug/metanx-l-methylfolate-pyridoxal-5-phosphate-methylcobalamin-999834

Health Solutions From Our Sponsors