Reviewed on 1/28/2022

Brand Name: Methergine

Generic Name: Methylergonovine

Drug Class: Ergot Derivatives

What Is Methylergonovine and How Does It Work?

Methylergonovine is a prescription medication used to treat Postpartum Hemorrhage

  • Methylergonovine is available under the following different brand names: Methergine

What Are Dosages of Methylergonovine?

Adult dosage

Injectable solution

  • 0.2mg/mL


  • 0.2mg

Postpartum Hemorrhage

Adult dosage

  • 0.2 mg IM/IV every 2-4 hours as needed; not to exceed 5 doses, then 0.2-0.4 mg orally every 6-8 hours as needed for 2-7 days
  • Administer IV only in an emergency because of potential for hypertension and CVA
  • Administer over 1 minute and monitor blood pressure

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”.

What Are Side Effects Associated with Using Methylergonovine?

Common side effects of Methylergonovine include:

Serious side effects of Methylergonovine include:

Rare side effects of Methylergonovine include:

  • none 
This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.


What is pelvic inflammatory disease (PID)? See Answer

What Other Drugs Interact with Methylergonovine?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

  • Methylergonovine has severe interactions with at least 33 other drugs. 
  • Methylergonovine has serious interactions with at least 51 other drugs.
  • Methylergonovine has moderate interactions with at least 40 other drugs. 
  • Methylergonovine has minor interactions with no other drugs. 

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this drug, tell your doctor or pharmacist of all the drugs you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Methylergonovine?


Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Methylergonovine?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Methylergonovine?”


Pregnancy and Lactation

  • Use with caution if the benefits outweigh the risks.  


  • Excreted in milk; adverse effect on nursing infants; may inhibit lactation; not recommended.  
  • Wait at least 12 hours after the last dose to breastfeed.
Medscape. Methylergonovine.

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