Reviewed on 8/30/2021


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What Is Aluminum Hydroxide/Magnesium Hydroxide/Simethicone Used For and How Does it Work?

Aluminum hydroxide/magnesium hydroxide/simethicone is an over-the-counter (OTC) product used for indigestion/heartburn (dyspepsia) and abdominal bloating.

Aluminum hydroxide/magnesium hydroxide/simethicone is available under the following different brand names: Mylanta, Mygel, DiGel, Gelusil, and Rulox.

Dosages of Aluminum Hydroxide/Magnesium Hydroxide/Simethicone


  • (200mg/200mg/20mg)/5mL
  • (400mg/400mg/40mg)/5mL


  • (225mg/200mg/25mg)/5mL

Dosage Considerations – Should be Given as Follows:

Dyspepsia, Abdominal Bloating

  • 10-20 mL orally every 4-6 hours taken 1 hour before or 3 hours after meals, OR
  • Chew 2-4 tablets every 4-6 hours; not to exceed 12 tablets/24 hours
  • Safety and efficacy not established in pediatric patients

What Are Side Effects Associated with Using Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?

Common side effects of Aluminum Hydroxide/Magnesium Hydroxide/Simethicone include:

Aluminum hydroxide

  • Chalky taste
  • Constipation
  • Fecal impaction
  • Stomach cramps
  • Nausea
  • Vomiting
  • Rebound hyperacidity
  • Aluminum intoxication
  • Low blood phosphate (hypophosphatemia)
  • Milk-alkali syndrome
  • Softening of bones

Magnesium hydroxide


  • Loose stools

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?

  • Severe interactions of Acetaminophen Dextromethorphan Phenylephrine include:
    • pazopanib
    • raltegravir
  • Aluminum hydroxide/magnesium hydroxide/simethicone has serious interactions with at least 30 different drugs.
  • Aluminum hydroxide/magnesium hydroxide/simethicone has moderate interactions with at least 128 different drugs.
  • Aluminum hydroxide/magnesium hydroxide/simethicone has mild interactions with at least 60 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?


This medication contains aluminum hydroxide/magnesium hydroxide/simethicone. Do not take Mylanta, Mygel, DiGel, Gelusil, or Rulox if you are allergic to aluminum hydroxide/magnesium hydroxide/simethicone or any ingredients contained in this drug.


  • Hypersensitivity to any component of the formulation

Effects of Drug Abuse

  • No information available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?"


  • Caution in renal failure
  • May increase or decrease rate and/or degree of absorption of concomitantly administered oral drugs by changing gastrointestinal (GI) transit time or by binding the drug
  • Magnesium-restricted diet
  • Similar trade names may have different compositions
  • Do not use combination product for hyperphosphatemia

Pregnancy and Lactation

Use hydroxide/magnesium hydroxide/simethicone with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.

It is unknown if hydroxide/magnesium hydroxide/simethicone is excreted in breast milk. Consult your doctor before breastfeeding.


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