Neomycin/Polymyxin B/Bacitracin/Pramoxine

Reviewed on 8/30/2021

What Is Neomycin/Polymyxin B/Bacitracin/Pramoxine and How Does It Work?

Neomycin/polymyxin B/bacitracin/pramoxine is an over-the-counter (OTC) product used for skin infection prevention.

Neomycin/polymyxin B/bacitracin/pramoxine is available under the following different brand names: Neosporin Plus Pain Relief Ointment and TriBiozene Ointment.

What Are the Dosages of Neomycin/Polymyxin B/Bacitracin/Pramoxine?

Dosages of Neomycin/Polymyxin B/Bacitracin/Pramoxine:

Dosage Forms and Strengths

Topical Ointment

  • (3.5mg/10,000units/500units/10mg)/g

Dosage Considerations – Should be Given as Follows:

Skin Infection Prevention

  • Apply a small amount to cleansed wound 1-3 times/day; not to exceed 1week

What Are Side Effects Associated with Using Neomycin/Polymyxin B/Bacitracin/Pramoxine?

Side effects of neomycin/polymyxin B/bacitracin/pramoxine include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Neomycin/Polymyxin B/Bacitracin/Pramoxine?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Neomycin/polymyxin B/bacitracin/pramoxine has no listed severe interactions with other drugs.
  • Neomycin/polymyxin B/bacitracin/pramoxine has no listed serious interactions with other drugs.
  • Neomycin/polymyxin B/bacitracin/pramoxine has no listed moderate interactions with other drugs.
  • Neomycin/polymyxin B/bacitracin/pramoxine has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

QUESTION

Bowel regularity means a bowel movement every day. See Answer

What Are Warnings and Precautions for Neomycin/Polymyxin B/Bacitracin/Pramoxine? 

Warnings

  • This medication contains neomycin/polymyxin B/bacitracin/pramoxine. Do not take Neosporin Plus Pain Relief Ointment or TriBiozene Ointment if you are allergic to neomycin/polymyxin B/bacitracin/pramoxine or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Hypersensitivity

Effects of Drug Abuse

  • No information is available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Neomycin/Polymyxin B/Bacitracin/Pramoxine?”

Long-Term Effects

  • See "What Are Side Effects Associated with Using Neomycin/Polymyxin B/Bacitracin/Pramoxine?”

Cautions

  • Ototoxicity (ear) and nephrotoxicity (kidney) are possible if treating large surface area or chronic use

Pregnancy and Lactation

  • Use neomycin/polymyxin B/bacitracin/pramoxine with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • It is unknown if neomycin/polymyxin B/bacitracin/pramoxine is excreted in breast milk. Systemic absorption of topical lidocaine has been reported.
  • Pregnant or breastfeeding patients should seek the advice of a health professional before using over-the-counter (OTC) drugs.
References
https://reference.medscape.com/drug/neosporin-plus-pain-relief-ointment-tribiozene-ointment-neomycin-polymyxin-b-bacitracin-pramoxine-999349

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