Nicotine Intranasal

Reviewed on 8/19/2021

Brand Name: Nicotrol NS
Generic Name: Nicotine Intranasal
Drug Class: Smoking Cessation Aids

What Is Nicotine Intranasal and How Does It Work?

Nicotine intranasal is used for nicotine replacement therapy to reduce withdrawal symptoms during smoking cessation.

Nicotine intranasal is available under the following different brand names: Nicotrol NS.

What Are the Dosages of Nicotine Intranasal?

Dosages of Nicotine Intranasal:

Dosage Forms and Strengths

Intranasal Spray

  • 0.5mg/actuation

Dosage Considerations – Should be Given as Follows:

Smoking Cessation

  • Nicotine replacement therapy to reduce withdrawal symptoms during smoking cessation
  • 1 spray/nostril (i.e., 2 sprays to provide 1 mg/dose); typically 10-12 sprays/day in each nostril as needed
  • Initiate with 1-2 doses/hour; for greatest success, instruct patient to use at least 8 doses/day initially
  • Depending on individual addiction; may increase up to a maximum dose of 40 mg (80 sprays/day)

Administration

  • Tilt the head back when administering
  • Do not sniff, swallow, or inhale through the nose as the spray is being administered
  • Safety and efficacy not established in pediatric patients

What Are Side Effects Associated with Using Nicotine Intranasal?

Common side effects of nicotine intranasal include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Nicotine Intranasal?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Nicotine intranasal has no listed severe interactions with other drugs.
Nicotine intranasal has no listed serious interactions with other drugs.
 

Moderate interactions of nicotine intranasal include:

  • adenosine
  • cimetidine
  • esketamine intranasal
  • green tea
  • naphazoline
  • oxymetholone
  • phenylephrine nasal
  • propylhexedrine
  • solriamfetol
  • varenicline
  • xylometazoline

Mild interactions of nicotine intranasal include:

  • bupropion
  • dihydroergotamine
  • dihydroergotamine intranasal
  • niacin
  • rose hips

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

QUESTION

What is the average weight gain for those who quit smoking? See Answer

What Are Warnings and Precautions for Nicotine Intranasal? 

Warnings
 

This medication contains nicotine intranasal. Do not take Nicotrol NS if you are allergic to nicotine intranasal or any ingredients contained in this drug.


Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Hypersensitivity

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Nicotine Intranasal?”

Long-Term Effects

  • See "What Are Side Effects Associated with Using Nicotine Intranasal?”

Cautions

Pregnancy and Lactation

Use nicotine intranasal during pregnancy only in LIFE-THREATENING emergencies when no safer drug is available. There is positive evidence of human fetal risk.

Nicotine intranasal is distributed in breast milk. The milk to plasma ratio is 2.9. Consult your doctor before breastfeeding.

References
https://reference.medscape.com/drug/nicotrol-ns-nicotine-intranasal-999837

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