Pentaerythritol Tetranitrate

Reviewed on 9/17/2021

Brand Name: Duotrate, Pentylan, Peritrate

Generic Name: Pentaerythritol Tetranitrate

Drug Class: Nitrates, Angina

What Is Pentaerythritol Tetranitrate Used For and How Does it Work?

Pentaerythritol tetranitrate is used for the treatment and prevention of angina pectoris.

Pentaerythritol tetranitrate is not available in the U.S.

Pentaerythritol tetranitrate is available under the following different brand names: Duotrate, Pentylan, and Peritrate.

What Are the Dosages of Pentaerythritol Tetranitrate?

Dosages of Pentaerythritol Tetranitrate:

  • Not specified

Dosage Considerations – Should be Given as Follows:

Angina Pectoris (Treatment and Prevention)

  • 10-20 mg orally four times daily, may increase to 40 mg four times daily

Erythrityl Tetranitrate (Cardilate)

  • 10 mg orally/SL as needed to no more than 100 mg/day

Other Information

  • Take 1/2 hour before or 1 hour after meals and at bedtime
  • SR: 80 mg orally twice daily on an empty stomach
  • Gradually decrease dose to avoid withdrawal reaction
  • Not FDA approved in children

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What Are Side Effects Associated with Using Pentaerythritol Tetranitrate?

Side effects of Pentaerythritol Tetranitrate may include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Pentaerythritol Tetranitrate?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Pentaerythritol tetranitrate has no listed severe interactions with other drugs.
  • Serious interactions of pentaerythritol tetranitrate include:
  • Moderate interactions of pentaerythritol tetranitrate include:
  • Pentaerythritol tetranitrate has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Pentaerythritol Tetranitrate?

Warnings

  • This medication contains pentaerythritol tetranitrate. Do not take Duotrate, Pentylan, or Peritrate if you are allergic to pentaerythritol tetranitrate or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Recent (last 24 hours) Sildenafil (Viagra) or other PDE5 inhibitor use: potential for dangerous hypotension
  • Hypersensitivity
  • Severe anemia

Effects of Drug Abuse

  • No information is available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Pentaerythritol Tetranitrate?"

Long-Term Effects

  • Gradually decrease dose to avoid withdrawal reaction.
  • See "What Are Side Effects Associated with Using Pentaerythritol Tetranitrate?"

Cautions

Pregnancy and Lactation

  • Use pentaerythritol tetranitrate with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • It is unknown whether pentaerythritol tetranitrate crosses into breast milk. Use caution while breastfeeding.

QUESTION

In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer
References
https://reference.medscape.com/drug/duotrate-pentylan-pentaerythritol-tetranitrate-342279

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