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Medical and Pharmacy Editor:

Brand Name: Trental, Pentoxil, Pentoxifylline SR

Generic Name: Pentoxifylline

Drug Class: Hemorheologic Agents

What Is Pentoxifylline and How Does It Work?

Pentoxifylline is a prescription drug used to improve the symptoms of a certain blood flow problem in the legs/arms (intermittent claudication due to occlusive artery disease). Pentoxifylline can decrease the muscle aching/pain/cramps during exercise, including walking, that occur with intermittent claudication. Pentoxifylline belongs to a class of drugs known as hemorrheologic agents. It works by helping blood flow more easily through narrowed arteries. This increases the amount of oxygen that can be delivered by the blood when the muscles need more (such as during exercise) thereby increasing walking distance and duration.

Pentoxifylline is available under the following different brand names: Trental, Pentoxil, and Pentoxifylline SR.

Dosage of Pentoxifylline:

Tablet, extended release

  • 400 mg

Dosing Considerations – Should be Given as Follows:

Adult Dosage only, safety and efficacy not established for pediatric dosages.

Intermittent Claudication

  • 400 mg orally every 8 hours
  • Recommended duration of treatment: not over 8 weeks

Dosage Modifications

  • Digestive or CNS side effects: Decrease dose to 400 mg twice daily; discontinue if adverse effects persist
  • Renal impairment (Creatinine Clearance under 30 mL/min): Decrease dose to 400 mg/day
  • Hepatic impairment: No information


  • Take with meals
Medically Reviewed by a Doctor on 6/9/2017

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