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Phenazopyridine

Medical and Pharmacy Editor:

Brand Name(s): Azo Standard, Pyridium, Prodium, Pyridiate, Baridium, Uricalm, Urodine, UTI Relief

Generic Name: Phenazopyridine

Drug Class: Alpha1 Agonists

What Is Phenazopyridine and How Does It Work?

Phenazopyridine is used to relieve symptoms caused by irritation of the urinary tract such as pain, burning, and the feeling of needing to urinate urgently or frequently. Phenazopyridine does not treat the cause of the urinary irritation, but it can help relieve the symptoms while other treatments take effect. Phenazopyridine is a dye that works as a painkiller to soothe the lining of the urinary tract.

Phenazopyridine is available under the following different brand names: Azo Standard, Pyridium, Prodium, Pyridiate, Baridium, Uricalm, Urodine, and UTI Relief.

Dosages of Phenazopyridine

Adult and Pediatric Dosage Forms and Strengths

Tablets

  • 95 mg
  • 97.2 mg
  • 100 mg
  • 200 mg

Dosage Considerations – Should be Given as Follows:

Dysuria, Irritation of Lower Urinary Tract Mucosa

100-200 mg orally after meals three times daily

Children under 6 years: Safety and efficacy not established

Children 6-12 years: 12 mg/kg/day orally after meals, divided every 8 hours

Children over 12 years: 100-200 mg orally after meals three times daily

Dosing considerations

Administration

What Are Side Effects Associated with Using Phenazopyridine?

Common side effects of phenazopyridine include:

Serious side effects of phenazopyridine include:

  • Pale skin
  • Fever
  • Confusion
  • Weakness
  • Jaundice (yellowing of your skin or eyes)
  • Urinating less than usual or not at all
  • Drowsiness
  • Mood changes
  • Increased thirst
  • Loss of appetite
  • Nausea
  • Vomiting
  • Swelling
  • Weight gain
  • Shortness of breath
  • Blue or purple coloring in your skin

This is not a complete list of side effects and other serious side effects may occur. Call your doctor for information and medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What Other Drugs Interact with Phenazopyridine?

If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Do not start, stop, or change the dosage of this medicine or any medicine before getting further information from your doctor, healthcare provider or pharmacist first.

Phenazopyridine has no known severe interactions with other drugs.

Phenazopyridine has no known serious interactions with other drugs.

Moderate Interactions of phenazopyridine include:

  • prilocaine

Phenazopyridine has no known mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Phenazopyridine?

Warnings

This medication contains phenazopyridine. Do not take Azo Standard, Pyridium, Prodium, Pyridiate, Baridium, Uricalm, Urodine, or UTI Relief if you are allergic to phenazopyridine or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Hypersensitivity
  • Renal impairment (CrCl less than 50mL/min)

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • Changes urine color; may affect urinalysis based on spectrometry or color reactions.
  • May stain contact lenses.
  • May stain fiber or clothing.
  • See "What Are Side Effects Associated with Using Phenazopyridine?"

Long-Term Effects

  • Self-medication should not continue more than 2 days; if pain persists, consult physician.
  • See "What Are Side Effects Associated with Using Phenazopyridine?"

Cautions

  • Changes urine color; may affect urinalysis based on spectrometry or color reactions.
  • May stain contact lenses.
  • Discontinue if yellowish color of skin or sclera, as this is an indication of drug accumulation due to renal failure; monitor geriatric patients due to greater risk.
  • Self-medication should not continue more than 2 days; if pain persists, consult physician.
  • Intended as analgesic, not for treatment of urinary tract infection (UTI).
  • Use caution in patients with G6PD deficiency; hemolytic anemia may occur in the setting of chronic overdose.
  • Not for treatment of urinary infection; acts only as analgesic.
  • Discontinue over the counter use if symptoms last more than 2 days or adverse effects occur.
  • May stain fiber or clothing.

Pregnancy and Lactation

  • Phenazopyridine may be acceptable for use during pregnancy. Either animal studies show no risk but human studies are not available or animal studies showed minor risks and human studies were done and showed no risk.
  • It is not known if phenazopyridine is excreted in breast milk; exercise caution if breastfeeding.
Reviewed on 1/3/2018


Medscape. Phenazopyridine.
https://reference.medscape.com/drug/azo-standard-pyridium-phenazopyridine-343349
DailyMed. Pyridium.
https://www.rxlist.com/pyridium-side-effects-drug-center.htm

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