Brand Name: Actos
Generic Name: Pioglitazone
Drug Class: Antidiabetics, Thiazolidinediones
What Is Pioglitazone and How Does It Work?
Pioglitazone exerts its antihyperglycemic effect only in the presence of endogenous insulin. Pioglitazone should not be used to treat type 1 diabetes or diabetic ketoacidosis, as it would not be effective in these settings.
Pioglitazone is available under the following different brand names: Actos.
Dosages of Pioglitazone:
- 15 mg
- 30 mg
- 45 mg
Dosage Considerations – Should be Given as Follows:
Type 2 Diabetes Mellitus
- Indicated as monotherapy or with insulin or insulin secretagogues
- 15-30 mg orally with meal every daily initially; may increase dose by 15 mg with careful monitoring to 45 mg each day
- Monitor ALT at start of treatment, each month for 12 months, then every 3 months thereafter
- Coadministration with insulin secretagogue (sulfonylurea): Decrease insulin secretagogue dose
- Coadministration with insulin: Decrease insulin dose by 10-25%
- Coadministration with strong CYP2C8 inhibitors (gemfibrozil): Limit maximum pioglitazone dose to 15 mg daily
Not recommended for pediatric use
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