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Medical and Pharmacy Editor:

Brand Name: Pipracil

Generic Name: Piperacillin

Drug Class: Penicillins, Extended-Spectrum

What Is Piperacillin and How Does It Work?

Piperacillin is an antibiotic used to treat infections caused by certain types of bacteria.

Piperacillin is available under the following different brand names: Pipracil.

Dosages of Piperacillin:

Dosage Forms and Strengths

Powder for injection

  • 2 mg
  • 3 mg
  • 4 mg
  • 40 mg

Dosage Considerations – Should be Given as Follows:

Usual Dosage Range

  • Adult, Intravenous (IV): 3-4 g/dose every 4-6 hours; not to exceed 24 g/24 hours
  • Adult, Intramuscular (IM): 2-3 g/dose every 6-12 hours; not to exceed 24 g/24 hours
  • Neonates: 100 mg/kg IV/IM every 12 hours
  • Infants and Children: 200-300 mg/kg/day IV/IM divided every 4-6 hours
  • Geriatric, IV: 2-4 g every 6-8 hours
  • Geriatric, IM: 1-2 g every 8-12 hours

Urinary Tract, Uncomplicated

  • 6-8 g/day intravenous/intramuscular (IV/IM) (100 to 125 mg/kg/day) divided every 6-12 hours

Community-Acquired Pneumonia

  • 6-8 g/day intravenous/intramuscular (IV/IM) (100 to 125 mg/kg/day) divided every 6-12 hours

Acute Cholangitis

  • 4 g intravenous (IV) every 6 hours

Moderate Infections

  • 2-3 g/dose intravenous/intramuscular (IV/IM) every 6-12 hours; not to exceed 2 g IM/site

Severe Infections

  • 3-4 g intravenous/intramuscular (IV/IM) every 4-6 hours; not to exceed 24 g/24 hours

Uncomplicated Gonorrhea

  • 2 g once with 1 g probenecid 30 min before injection

Pseudomonas Infections

  • 4 g intravenous/intramuscular (IV/IM) every 4 hours

Cystic Fibrosis, Pediatric

  • 350-500 mg/kg/day intravenous/intramuscular (IV/IM) divided every 4-6 hours

Renal Impairment

  • CrCl 20-40 mL/minute: 3-4 g every 8 hours
  • CrCl less than 20 mL/minute: 3-4 g every 12 hours

Other Indications and Uses

  • Extended spectrum: Acinetobacter spp., Alcaligenes xylosoxidans, Bacteroides spp., Citrobacter diversus, Citrobacter freundii, E. coli, Fusobacteriae, H. influenzae, Klebsiella spp., N. gonorrhoeae, Peptococcus spp., Peptostreptococcus spp., indole-pos. Proteus spp., Providencia spp., Pseudomonas spp., Serratia spp., Streptococcus faecalis, Yersinia enterolitica
Medically Reviewed by a Doctor on 8/9/2017

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