Plasma Protein Fraction

Reviewed on 9/20/2021

What Is Plasma Protein Fraction Used For and How Does it Work?

Plasma protein fraction is used to treat shock and low blood volume (hypovolemia).

Plasma protein fraction is available under the following different brand names: Plasma Plex, Plasmanate, Plasmatein, and Protenate.

What Are the Dosages of Plasma Protein Fraction?

Dosages of Plasma Protein Fraction:

Adult and Pediatric Dosage Forms and Strengths

Injectable Solution

  • 5%

Dosage Considerations – Should be Given as Follows:

Treatment of Shock

  • Adults: 250-500 mL (12.5-25 g of protein) intravenously (IV) as needed based on response
  • Safety and efficacy not established in pediatric patients; useful in infants and small children for initial treatment of shock resulting from dehydration and infection
  • Children: 6.6-33 mL/kg (0.33-1.65 g/kg of protein) IV infusion at 5-10 mL/minute as needed
  • Monitor for signs of hypervolemia

Hypovolemia

  • 250-500 mL (12.5-25 g of protein) IV as needed based on response

SLIDESHOW

Anemia Symptoms and Signs, Types, Treatment and Causes See Slideshow

What Are Side Effects Associated with Using Plasma Protein Fraction?

Side effects of Plasma Protein Fraction include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Plasma Protein Fraction?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Plasma Protein Fraction has no listed severe interactions with other drugs.
  • Plasma Protein Fraction has no listed serious interactions with other drugs.
  • Plasma Protein Fraction has no listed moderate interactions with other drugs.
  • Plasma Protein Fraction has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Plasma Protein Fraction?

Warnings

  • This medication contains a plasma protein fraction. Do not take Plasma Plex, Plasmanate, Plasmatein, or Protenate if you are allergic to plasma protein fraction or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

Effects of Drug Abuse

  • No information is available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Plasma Protein Fraction?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Plasma Protein Fraction?"

Cautions

  • Allergy to corn, liver disease, renal impairment
  • Risk of pulmonary edema or congestive heart failure
  • Ineffective in chronic cases of nephrosis, cirrhosis, malabsorption, enteropathies

Pregnancy and Lactation

  • Use plasma protein fraction with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • It is not known if plasma protein fraction is distributed into breast milk. Avoid the use of plasma protein fractions while breastfeeding.

QUESTION

What is hemophilia? See Answer
References
https://reference.medscape.com/drug/plasma-plex-plasmanate-plasma-protein-fraction-342428

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