Potassium Acid Phosphate

Reviewed on 9/17/2021

What Is Potassium Acid Phosphate Used For and How Does it Work?

Potassium acid phosphate is used to treat elevated urinary pH.

Potassium acid phosphate is available under the following different brand names: KPhos Original and NeutraPhos.

What Are the Dosages of Potassium Acid Phosphate?

Dosages of Potassium Acid Phosphate:

Dosage Forms and Strengths


  • 500 mg

Dosage Considerations – Should be Given as Follows:

Elevated Urinary pH

  • 1-2 tabs (500-1000mg) dissolved in 6-8 oz of water; take orally four times daily with meals and at bedtime

Safety and efficacy not established in pediatric patients.


About how much does an adult human brain weigh? See Answer

What Are Side Effects Associated with Using Potassium Acid Phosphate?

Side effects of Potassium Acid Phosphate may include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Potassium Acid Phosphate?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Potassium Acid Phosphate has no listed severe interactions with other drugs.
  • Serious interactions of potassium acid phosphate include:
  • Potassium Acid Phosphate has moderate interactions with at least 107 different drugs.
  • Potassium Acid Phosphate has mild interactions with at least 30 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Potassium Acid Phosphate?


  • This medication contains Potassium Acid Phosphate. Do not take Zydelig if you are allergic to potassium_acid_phosphate or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


Effects of Drug Abuse

  • No information is available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Potassium Acid Phosphate?"

Long-Term Effects

  • Hemosiderosis (during long-term administration of large amounts)


  • May cause high blood potassium (hyperkalemia); use caution in patients who require regulation of serum potassium concentrations
  • Patients may experience mild laxative effects within the first few days of therapy
  • Use caution in patients with severe adrenal insufficiency, cardiac disease, myotonia congenita, pancreatitis, parathyroid disease, renal calculi, renal impairment, tissue breakdowns (burns), or rickets

Pregnancy and Lactation

  • Use potassium acid phosphate with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • It is not known whether potassium acid phosphate crosses into breast milk. Use caution while breastfeeding.


Digestive Disorders: Common Misconceptions See Slideshow

Health Solutions From Our Sponsors