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Prednisone

Medical and Pharmacy Editor:

Brand Name(s): Deltasone, Rayos, Prednisone Intensol, Sterapred, and Sterapred DS

Generic Name: prednisone

Drug Class: Corticosteroids

What Is Prednisone and How Does It Work?

Prednisone is a prescription medication used most commonly to treat diseases affecting endocrine, rheumatic, collagen, dermatologic, ophthalmic, respiratory, neoplastic, gastrointestinal diseases, allergic reactions, hematologic disorders, edematous conditions, and disorders of the nervous system.

Prednisone is available under the following different brand names: Deltasone, Rayos, Prednisone Intensol, Sterapred, and Sterapred DS.

Dosages of Prednisone

Adult and pediatric dosages:

Concentrate

  • 5 mg/mL

Oral solution

  • 5 mg/5mL

Tablet

  • 1 mg
  • 2.5 mg
  • 5 mg
  • 10 mg
  • 20 mg
  • 50 mg

Dosage Considerations – Should be Given as Follows:

Administration

Prednisone should be taken with meal or snack. High-dose glucocorticoids may cause insomnia; and immediate-release formulation is typically administered in morning to coincide with circadian rhythm.

Delayed-release formulation takes about 4 hours to release active substances. With this formulation, timing of dose should take into account as to the delayed-release pharmacokinetics and the disease or condition being treated (for example, the medication may be taken at bedtime to decrease morning stiffness with rheumatoid arthritis).

Adult

Glucocorticoid-Responsive Conditions

5-60 mg/day orally in single daily dose or divided every 6 to 12 hours.

Dosing considerations

When converting from immediate-release to delayed-release formulation, note that delayed-release formulation takes about 4 hours to release active substances.

Note that exogenous steroids suppress adrenal cortex activity least during maximal natural adrenal cortex activity (between 4:00 and 8:00 AM).

Acute Asthma

Adult: 40-60 mg/day orally in single daily dose or divided every 12 hours for 3-10 days

Children younger than 12 years: 1-2 mg/kg/day orally in single daily dose or divided every 12 hours for 3-10 days; not to exceed 80 mg/day.

Children 12 years or older: 40-60 mg/day orally in single daily dose or divided every 12 hours for 3-10 days

Giant Cell Arteritis

40-60 mg orally every day (1-2 years usual duration of treatment).

Idiopathic Thrombocytopenic Purpura

1-2 mg/kg/day orally.

Dose Tapering

Day 1: 10 mg orally before breakfast, 5 mg after lunch and after dinner, and 10 mg at bedtime

Day 2: 5 mg orally before breakfast, after lunch, and after dinner and 10 mg at bedtime

Day 3: 5 mg orally before breakfast, after lunch, after dinner, and at bedtime

Day 4: 5 mg orally before breakfast, after lunch, and at bedtime

Day 5: 5 mg orally before breakfast and at bedtime

Day 6: 5 mg orally before breakfast

Rheumatoid Arthritis

Immediate-release: Greater than or equal to 10 mg/day orally added to disease-modifying anti-rheumatic drugs.

Delayed-release: 5 mg/day orally initially; maintenance: lowest dosage that maintains clinical response; may be taken at bedtime to decrease morning stiffness with rheumatoid arthritis.

Advanced Pulmonary/Extra pulmonary Tuberculosis

40-60 mg/day orally, tapered over 4-8 weeks

Pneumocystis (carinii) jiroveci Pneumonia in Patients With AIDS (Off-label)

Adult: 40 mg orally every 12 hours for 5 days, then 40 mg orally every 24 hours for 5 days, then 20 mg every 24 hours for 11 days.

Children younger than 12 years: 1 mg/kg orally every 12 hours for 5 days, then 0.5-1 mg/kg orally every 12 hours for 5 days, then 0.5 mg/kg orally every 24 hours for 11-21 days.

Children 12 years or older: 40 mg orally every 12 hours for 5 days, then 40 mg orally every 24 hours for 5 days, then 20 mg orally every 24 hours for 11 days.

Crohn's Disease (Off-label)

40-60 mg orally every day until resolution and resumption of weight gain (7-28 days usual duration).

Autoimmune Hepatitis

60 mg orally once a day for 1 week; then 40 mg orally once a day for 1 week; then 30 mg once a day for 2 weeks; followed by 20 mg orally once a day; give half this dose if giving in combination with azathioprine.

Pediatric

Inflammation

0.5-2 mg/kg/day orally in single daily dose or divided every 12 hours; not to exceed 80 mg/day.

Nephrotic Syndrome

2 mg/kg/day orally; not to exceed 80 mg/day

Medically Reviewed by a Doctor on 3/27/2017



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