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Preparation H

Brand Name: Preparation H Cream Maximum Strength Pain Relief
Generic Name: Phenylephrine/Pramoxine/Glycerin/Petrolatum Rectal
Drug Class: Gastrointestinal Agents, Other

What Is Phenylephrine/Pramoxine/Glycerin/Petrolatum Rectal and How Does It Work?

Phenylephrine/pramoxine/glycerin/petrolatum rectal is an over-the-counter (OTC) product used to treat hemorrhoids.

Phenylephrine/pramoxine/glycerin/petrolatum rectal is available under the following different brand names: Preparation H Cream Maximum Strength Pain Relief.

Dosages of Phenylephrine/Pramoxine/Glycerin/Petrolatum Rectal:

Dosage Forms and Strengths

Rectal Ointment

  • 0.25%/1%/14.4%/15%

Dosage Considerations – Should be Given as Follows:

Hemorrhoids

  • Adults and children 12 years and older: May apply up to 4 times/day, especially at night, in the morning, or after bowel movement that may exacerbate hemorrhoid(s)
  • Apply to cleansed area externally or in the lower portion of the anal canal
  • Children under 12 years: Use is dependent on patient and if benefit outweighs risk
  • Administration
  • For application in the lower anal canal, remove cover from dispensing cap and attach dispensing cap to tube
  • Intrarectal use: Remove cover from applicator and attach applicator to ointment tube, lubricate applicator well and gently insert applicator into rectum; clean applicator after each use and replace cover.

What Are Side Effects Associated with Using Phenylephrine/Pramoxine/Glycerin/Petrolatum Rectal?

Side effects of phenylephrine/pramoxine/glycerin/petrolatum rectal include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Phenylephrine/Pramoxine/Glycerin/Petrolatum Rectal?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Phenylephrine/pramoxine/glycerin/petrolatum rectal has no listed severe interactions with other drugs.
  • Phenylephrine/pramoxine/glycerin/petrolatum rectal has no listed serious interactions with other drugs.
  • Phenylephrine/pramoxine/glycerin/petrolatum rectal has no listed moderate interactions with other drugs.
  • Phenylephrine/pramoxine/glycerin/petrolatum rectal has no listed mild interactions with other drugs.
     

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

SLIDESHOW

How to Get Rid of Hemorrhoids: Types, Causes and Treatments See Slideshow

What Are Warnings and Precautions for Phenylephrine/Pramoxine/Glycerin/Petrolatum Rectal? 

Warnings
 

This medication contains phenylephrine/pramoxine/glycerin/petrolatum rectal. Do not take Preparation H Cream Maximum Strength Pain Relief if you are allergic to phenylephrine/pramoxine/glycerin/petrolatum rectal or any ingredients contained in this drug.


Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Hypersensitivity

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Phenylephrine/Pramoxine/Glycerin/Petrolatum Rectal?”

Long-Term Effects

  • See "What Are Side Effects Associated with Using Phenylephrine/Pramoxine/Glycerin/Petrolatum Rectal?”

Cautions

  • For external use only
  • Contains phenylephrine, caution with heart disease, high blood pressure (hypertension), hyperthyroidism, diabetes, or prostatic hypertrophy
  • Discontinue and contact physician if hemorrhoids worsen or do not improved within 7 days
  • Discontinue if bleeding, allergic reaction, redness, irritation, swelling, pain, or other symptoms develop or increase

Pregnancy and Lactation

Use phenylephrine/pramoxine/glycerin/petrolatum rectal with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.

It is unknown if phenylephrine/pramoxine/glycerin/petrolatum rectal is distributed in breast milk.

Pregnant or breastfeeding patients should seek advice of a health professional before using over-the-counter (OTC) drugs.

Reviewed on 3/27/2020
References
https://reference.medscape.com/drug/preparation-h-cream-maximum-strength-pain-relief-phenylephrine-pramoxine-glycerin-petrolatum-rectal-999742
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