Reviewed on 8/6/2021

What Is Chlorpheniramine/Pyrilamine/Phenylephrine and How Does It Work?

Chlorpheniramine/pyrilamine/phenylephrine is used to treat allergy and cold and flu symptoms such as runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion.

Chlorpheniramine/pyrilamine/phenylephrine is available under the following different brand names: R-Tannate and Triplex AD Liquid.

What Are the Dosages of Chlorpheniramine/Pyrilamine/Phenylephrine?

Dosages of Chlorpheniramine/Pyrilamine/Phenylephrine:

  • 8 mg-25 mg-25 mg
  • 2 mg-5 mg-12.5 mg/5 mL
  • 4 mg-10 mg-25 mg
  • 2 mg-10 mg-10 mg/5 mL
  • 2 mg-7.5 mg-12.5 mg/5 mL
  • 2 mg-10 mg-10 mg
  • 8 mg-15 mg-12.5 mg/5 mL

Dosage Considerations – Should be Given as Follows:

For Allergic Rhinitis and Cold and Flu Symptoms

Chlorpheniramine/phenylephrine/pyrilamine 2 mg-7.5 mg-12.5 mg/5 mL:

  • 5 to 10 mL orally every 4 to 6 hours not to exceed 60 mg of phenylephrine in 24 hours

Chlorpheniramine/phenylephrine/pyrilamine 4 mg-10 mg-25 mg oral tablet, extended-release:

  • 1 tablet orally 2 to 3 times daily

Chlorpheniramine/phenylephrine/pyrilamine 8 mg-12.5 mg-15 mg/5 mL:

  • 5 to 10 mL orally every 12 hours not to exceed 20 mL in 24 hours

Chlorpheniramine/phenylephrine/pyrilamine 2 mg-10 mg-10 mg oral tablet:

  • 1 to 2 tablets orally every 4 to 6 hours.

What Are Side Effects Associated with Using Chlorpheniramine/Pyrilamine/Phenylephrine?

Common side effects of chlorpheniramine/pyrilamine/phenylephrine include:

  • Nausea
  • Constipation
  • Loss of appetite
  • Rash or itching
  • Increased sweating
  • Dry mouth, nose, or throat
  • Blurred vision
  • Headache
  • Dizziness
  • Restlessness or excitability (especially in children)

Serious side effects of chlorpheniramine/pyrilamine/phenylephrine include:

  • Confusion
  • Hallucinations
  • Nervousness
  • Irritability
  • Trouble sleeping
  • Little or no urination
  • Seizures (convulsions)
  • Numbness or tingling
  • Lightheadedness
  • Pounding heartbeats or fluttering in your chest
  • Increased blood pressure (severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed)

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.


Which illness is known as a viral upper respiratory tract infection? See Answer

What Other Drugs Interact with Chlorpheniramine/Pyrilamine/Phenylephrine?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Chlorpheniramine/pyrilamine/phenylephrine may interact with:

  • Other cold, cough, allergy, or pain medicines
  • Alcohol
  • Other drugs that make you sleepy or slow your breathing (sleeping pills, narcotics, muscle relaxers, or medicines for anxiety, depression, or seizures)

Chlorpheniramine/pyrilamine/phenylephrine has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Chlorpheniramine/Pyrilamine/Phenylephrine? 


This medication contains chlorpheniramine/pyrilamine/phenylephrine. Do not take R-Tannate or Triplex AD Liquid if you are allergic to chlorpheniramine/pyrilamine/phenylephrine or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Chlorpheniramine/Pyrilamine/Phenylephrine?”

Long-Term Effects

  • See "What Are Side Effects Associated with Using Chlorpheniramine/Pyrilamine/Phenylephrine?”


  • Chlorpheniramine/pyrilamine/phenylephrine may impair thinking or reactions. Be careful driving or doing anything that requires alertness.
  • Drinking alcohol with this medicine can cause side effects.
  • Chlorpheniramine/pyrilamine/phenylephrine can make you sunburn more easily. Avoid exposure to sunlight or tanning beds.  

Pregnancy and Lactation

It is not known whether chlorpheniramine/pyrilamine/phenylephrine will harm a fetus. Consult your doctor before using chlorpheniramine/pyrilamine/phenylephrine if you are pregnant.

Chlorpheniramine/pyrilamine/phenylephrine passes into breast milk and may cause side effects in the nursing baby. Antihistamines can also slow breast milk production. Breastfeeding is not recommended while using chlorpheniramine/pyrilamine/phenylephrine.


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