Oxymetazoline Topical

Reviewed on 8/20/2021

What Is Oxymetazoline Topical Used For and How Does it Work?

Oxymetazoline topical is used for the topical treatment of persistent facial erythema associated with rosacea in adults.

Oxymetazoline topical is available under the following different brand names: Rhofade.

What Are the Dosages of Oxymetazoline Topical?

Dosages of Oxymetazoline Topical:

Dosage Forms and Strengths

Topical Cream

  • 1% (available in a tube or pump bottle)
  • Each gram of cream contains 10 mg (1%) oxymetazoline hydrochloride, which is equivalent to 8.8 mg (0.88%) of oxymetazoline free base

Dosage Considerations – Should be Given as Follows:

Rosacea

  • Indicated for the topical treatment of persistent facial erythema associated with rosacea in adults
  • Apply topically once daily; use a pea-sized amount of cream in a thin layer to cover the entire face (forehead, nose, each cheek, and chin), avoiding the eyes and lips
  • Wash hands immediately after application
  • Children under 18 years: Safety and efficacy not established

IMAGES

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What Are Side Effects Associated with Using Oxymetazoline Topical?

Common side effects of oxymetazoline_topical include:

  • Application-site dermatitis
  • Worsening inflammatory lesions of rosacea
  • Application-site itching
  • Application-site redness
  • Application-site pain

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Oxymetazoline Topical?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Oxymetazoline topical has no listed severe interactions with other drugs.
  • Oxymetazoline topical has no listed serious interactions with other drugs.
  • Oxymetazoline Topical has no listed moderate interactions with other drugs.
  • Oxymetazoline Topical has no listed mild interactions with other drugs.

What Are Warnings and Precautions for Oxymetazoline Topical?

Warnings

This medication contains agalsidase alfa. Do not take Replagal if you are allergic to agalsidase alfa or any ingredients contained in this drug.

Contraindications

  • None

Effects of Drug Abuse

  • No information is available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Oxymetazoline Topical?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Oxymetazoline Topical?"

Cautions

Drug interaction overview

  • Antihypertensives or cardiac glycosides: Alpha-adrenergic agonists, as a class, may increase blood pressure; caution with the coadministration of beta-blockers, antihypertensives, and/or cardiac glycosides
  • Monoamine oxidase (MAO) inhibitors: Caution is advised if co-administered with MAO inhibitors, which can affect the metabolism and uptake of circulating amines
  • Other alpha1 adrenergic receptor agonists: Use caution in patients receiving alpha1 adrenergic receptor antagonists (e.g., treatment of cardiovascular disease, benign prostatic hypertrophy, or Raynaud disease)

Pregnancy and Lactation

There are no available data on oxymetazoline topical use in pregnant women to inform a drug-associated risk for major birth defects and miscarriage. Data describing intranasal decongestant use in pregnant women identified a potential association between second-trimester exposure to oxymetazoline (with no decongestant exposure in the first trimester) and renal collecting system anomalies. Consult your doctor.

It is unknown if oxymetazoline topical is distributed in human breast milk. Oxymetazoline was detected in the milk of lactating rats. Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for oxymetazoline topical, and any potential adverse effects on the breastfed infant from the drug or the underlying maternal condition.

References
https://reference.medscape.com/drug/rhofade-oxymetazoline-topical-1000142

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