Tetrahydrozoline/Zinc Sulfate/Hypromellose

Reviewed on 9/2/2021

What Is Tetrahydrozoline/Zinc Sulfate/Hypromellose Ophthalmic and How Does It Work?

Tetrahydrozoline/zinc sulfate/hypromellose ophthalmic is an over-the-counter (OTC) product used to temporarily relieve discomfort due to minor ophthalmic (eye) irritations and redness.

Tetrahydrozoline/zinc sulfate/hypromellose ophthalmic is available under the following different brand names: Rohto Ice and Rohto Relief.

What Are the Dosages of Tetrahydrozoline/Zinc Sulfate/Hypromellose Ophthalmic?

Dosages of Tetrahydrozoline/Zinc Sulfate/Hypromellose Ophthalmic:

Dosage Forms and Strengths

Ophthalmic Solution

  • 0.05%/0.25%/0.2%

Dosage Considerations – Should be Given as Follows:

Ocular Redness and Irritation

  • Indicated to temporarily relieve discomfort due to minor ophthalmic irritations and redness
  • 1-2 drops in each eye as needed; not to exceed 4 doses/day

Administration

  • Do not touch the tip of the container to any surface to avoid contamination
  • Replace cap after each use
  • Do not use if the solution changes color or becomes cloudy
  • Remove contact lenses before use
  • What Are Side Effects Associated with Using Tetrahydrozoline/Zinc Sulfate/Hypromellose Ophthalmic?
  • Side effects of tetrahydrozoline/zinc sulfate/hypromellose ophthalmic include:
  • Increased intraocular pressure (IOP)
  • Transient blurred vision
  • Transient eye dryness
  • Transient eye burning/stinging
  • Rye redness (rebound conjunctival hyperemia)

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Are Side Effects Associated with Using Tetrahydrozoline/Zinc Sulfate/Hypromellose Ophthalmic?

Side effects of tetrahydrozoline/zinc sulfate/hypromellose ophthalmic include:

  • Increased intraocular pressure (IOP)
  • Transient blurred vision
  • Transient eye dryness
  • Transient eye burning/stinging
  • Rye redness (rebound conjunctival hyperemia)

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Tetrahydrozoline/Zinc Sulfate/Hypromellose Ophthalmic?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Tetrahydrozoline/zinc sulfate/hypromellose ophthalmic has no listed severe interactions with other drugs.
  • Tetrahydrozoline/zinc sulfate/hypromellose ophthalmic has no listed serious interactions with other drugs.
  • Tetrahydrozoline/zinc sulfate/hypromellose ophthalmic has no listed moderate interactions with other drugs.
  • Tetrahydrozoline/zinc sulfate/hypromellose ophthalmic has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

QUESTION

What causes dry eyes? See Answer

What Are Warnings and Precautions for Tetrahydrozoline/Zinc Sulfate/Hypromellose Ophthalmic? 

Warnings

  • This medication contains tetrahydrozoline/zinc sulfate/hypromellose ophthalmic. Do not take Rohto Ice or Rohto Relief if you are allergic to tetrahydrozoline/zinc sulfate/hypromellose ophthalmic or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Hypersensitivity

Effects of Drug Abuse

  • No information is available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Tetrahydrozoline/Zinc Sulfate/Hypromellose Ophthalmic?”

Long-Term Effects

  • See "What Are Side Effects Associated with Using Tetrahydrozoline/Zinc Sulfate/Hypromellose Ophthalmic?”

Cautions

Pregnancy and Lactation

  • Tetrahydrozoline/zinc sulfate/hypromellose ophthalmic may be acceptable for use during pregnancy. Either animal studies show no risk but human studies are not available or animal studies showed minor risks and human studies were done and showed no risk.
  • It is unknown if tetrahydrozoline/zinc sulfate/hypromellose ophthalmic is distributed in human breast milk.
  • Pregnant or breastfeeding patients should seek the advice of a health professional before using over-the-counter (OTC) drugs.
References
https://reference.medscape.com/drug/rohto-ice-rohto-relief-tetrahydrozoline-zinc-sulfate-hypromellose-ophthalmic-999916

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