Reviewed on 9/2/2021

Brand Name: Transderm Scop, Scopace, Maldemar

Generic Name: Scopolamine

Drug Class: Antiemetic Agents

What Is Scopolamine and How Does It Work?

Scopolamine is a prescription drug used in adults for prevention of nausea and vomiting.

  • Scopolamine is available under the following different brand names: Transderm Scop, Scopace, and Maldemar.

What Are Dosages of Scopolamine?

Dosages of Scopolamine:

Transdermal patch

  • 1 mg/75 hour

Dosage Considerations – Should be Given as Follows:

Nausea and Vomiting Treatment

Motion Sickness


  • Apply 1 patch behind the ear at least 4-12 hours before (preferably 12 hours) before an anticipated exposure to motion, then every 3 days as needed

Nausea and vomiting associated with anesthesia

  • Apply 1 patch behind the ear on the night before the scheduled surgery, then leave on for 24 hours after surgery
  • Cesarean section: Apply 1 patch behind the ear 1 hour before surgery (to minimize newborn exposure, apply no sooner); remove 24 hours after surgery

Chemotherapy-induced nausea and vomiting (off label)

  • Apply 1 patch every 72 hours


  • Safety and efficacy not established


Pancreatitis is inflammation of an organ in the abdomen called the pancreas. See Answer

What Are Side Effects Associated with Using Scopolamine ?

Side effects of scopolamine include:

Postmarketing side effects include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Scopolamine ?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Scopolamine has no known severe interactions with other drugs.
  • Serious interactions of scopolamine include:
    • pramlintide
  • Scopolamine has moderate interactions with 108 different drugs.
  • Mild interactions of scopolamine include:

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine.

What Are Warnings and Precautions for Scopolamine ?


  • This medication contains scopolamine. Do not take Transderm Scop, Scopace, or Maldemar if you are allergic to scopolamine or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


  • Hypersensitivity to scopolamine, belladonna alkaloids, or any component in the formulation
  • Closed-angle glaucoma

Effects of Drug Abuse

  • May cause withdrawal symptoms if used longer than 3 days

Short-Term Effects

  • May cause central nervous system depression; caution when operating heavy machinery or tasks which require mental alertness
  • See "What Are Side Effects Associated with Using Scopolamine?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Scopolamine?"


Pregnancy and Lactation

  • Use scopolamine during pregnancy with caution if benefits outweigh risks
  • Animal studies show risk and human studies are not available, or neither animal nor human studies were done
  • Scopolamine is distributed into breast milk; use caution if breastfeeding


Super Tips to Boost Digestive Health: Bloating, Constipation, and More See Slideshow
Medscape. Scopolamine.
RxList. Transderm Scop Indications.

Health Solutions From Our Sponsors