Reviewed on 8/30/2021

What Is Solithromycin Used For and How Does it Work?

Solithromycin is an antibiotic currently undergoing clinical trials for the treatment of community-acquired bacterial pneumonia (CABP) caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, methicillin-susceptible Staphylococcus aureus, Legionella pneumophila, and Mycoplasma pneumoniae.

Solithromycin is available under the following different brand names: Solithera.

What Are the Dosages of Solithromycin?

Dosages of Solithromycin:

  • Capsule, 200 mg
  • Injection, 400 mg

Dosage Considerations – Should be Given as Follows:

  • The recommended dose of solithromycin capsules is 800 mg orally once on day 1, followed by 400 mg orally once daily on days 2-5.
  • The recommended dose of solithromycin for injection is 400 mg intravenously (IV) once a day for 7 days; when switching to oral solithromycin, the applicant proposes a loading dose of 800 mg orally, followed by 400 mg orally daily to complete the 7-day course.


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What Are Side Effects Associated with Using Solithromycin?

Common side effects of solithromycin include:

  • drug-induced liver injury
  • infusion-site reactions

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Solithromycin?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Solithromycin may interact with:

  • CYP3A/P-gp inducers
  • CYP3A substrates
  • P-gp substrates

What Are Warnings and Precautions for Solithromycin?


  • This medication contains solithromycin. Do not take Solithera if you are allergic to solithromycin or any ingredients contained in this drug.


  • No information is available.

Effects of Drug Abuse

  • No information is available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Solithromycin?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Solithromycin?"


  • No information is available.

Pregnancy and Lactation

  • There is no information available regarding the use of solithromycin during pregnancy or while breastfeeding. Consult your doctor.

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