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Sumatriptan

Medical and Pharmacy Editor:

Brand Name: Imitrex, Imitrex Statdose, Sumavel DosePro, Alsuma, Zembrace SymTouch

Generic Name: sumatriptan

Drug Class: Serotonin 5-HT-Receptor Agonists; Antimigraine Agents

What Is Sumatriptan and How Does It Work?

Sumatriptan is indicated for the acute treatment of migraine, with or without aura, and the acute treatment of cluster headache.

Sumatriptan is available under the following different brand names: Imitrex, Imitrex Statdose, Sumavel DosePro, Alsuma, and Zembrace SymTouch.

Limitations of Use:

  • Use only if a clear diagnosis of migraine or cluster headache has been established. If a patient has no response to the first migraine or cluster headache attack treated with sumatriptan injection, reconsider the diagnosis before sumatriptan injection is administered to treat any subsequent attacks
  • Sumatriptan injection is not indicated for the prevention of migraine or cluster headache attacks

Dosages of Sumatriptan:

Dosage Forms and Strengths

Tablet, immediate-release

  • 25 mg
  • 50 mg
  • 100 mg

Injectable SC solution

  • 6 mg/0.5mL vial (Imitrex)

Prefilled SC syringe/cartridge

  • 3mg/0.5mL autoinjector (Zembrace SymTouch)
  • 4mg/0.5mL (Imitrex StatDosePen)
  • 6mg/0.5mL (Imitrex StatDosePen; Sumavel DosePro; Alsuma Autoinjector)

Dosage Considerations – Should be Given as Follows:

Migraine Headache

Tablet

  • 25 mg, 50 mg, or 100 mg orally (taken with fluids)
  • Not to exceed 100 mg/dose; additional doses every 2 hours as needed
  • Recommended maximum dose: 200 mg/day
  • See also combo with naproxen

Injection

  • 6 mg (0.5 mL) subcutaneously (SC) with autoinjector; may repeat in 1 hour or more
  • Not to exceed 12 mg SC every 24 hours
  • Dose may be reduced to 1-5 mg under certain circumstances; e.g., adverse reactions

Cluster Headache

  • 6 mg (0.5 mL) subcutaneously (SC) with autoinjector; may repeat in 1 hour or more
  • Not to exceed 12 mg SC every 24 hours
  • Dosing considerations
    • Dose may be reduced under certain circumstances; e.g., adverse reactions

Dosage Modifications

  • Mild to moderate hepatic impairment: Oral not to exceed 50 mg/dose; no dosage adjustments necessary if administered subcutaneously (SC) (use with caution)
  • Severe hepatic impairment: Contraindicated
  • Children under 18 years: Safety and efficacy not established
  • Geriatric use not recommended (higher incidence of adverse effects)
Medically Reviewed by a Doctor on 4/11/2017



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