Suramin

Suramin is used to treat trypanosomiasis and T.b. gambiense.

Suramin is available under the following different brand and other names: Suramin sodium.

Powder for Injectable Solution

• 1 g (reconstitute to100mg/mL)

Dosage Considerations – Should be Given as Follows:

Trypanosomiasis

• Adult: 100-200 mg (test dose) intravenously (IV), then 1 g IV on days 1, 3, 7, 14, 21
• Pediatric: 20 mg/kg IV on days 1, 3, 7, 14, 21; not to exceed 1 g/dose

TB Gambiense

• 10 mg/kg IV every 5 days to total of 12 injections
• May repeat after 1 month; use concomitantly with tryparsamide

Side effects of hydrocortisone/neomycin/polymyxin topical include:

• Vomiting
• Hives
• Numbness and tingling
• Nerve pain in extremities
• Kidney damage
• Blood disorders
• Increased urination
• Thirst
• Low red blood cells, white blood cells, and platelets (pancytopenia)
• Shock
• Optic atrophy

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Suramin has no listed severe interactions with other drugs.

Suramin has no listed serious interactions with other drugs.

Suramin has no listed moderate interactions with other drugs.

Suramin has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings

This medication contains hydrocortisone/neomycin/polymyxin topical. Do not use Cortisporin Cream if you are allergic to hydrocortisone/neomycin/polymyxin topical or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• Hypersensitivity

Effects of Drug Abuse

• No information available

Short-Term Effects

• See "What Are Side Effects Associated with Using Suramin?"

Long-Term Effects

• See "What Are Side Effects Associated with Using Suramin?"

Cautions

• Proteinuria and renal toxicity reported with use
• Avoid use in renal or hepatic impairment

Pregnancy and Lactation

There have been no human studies conducted of suramin use during pregnancy. Consult your doctor.

It is not known if suramin is excreted in breast milk. Consult your doctor before breastfeeding.