Polyethylene Glycol 400/Propylene Glycol Ophthalmic

Reviewed on 8/10/2021

What Is Polyethylene Glycol 400/Propylene Glycol Ophthalmic and How Does It Work?

Polyethylene glycol 400/propylene glycol ophthalmic is an over-the-counter (OTC) product used to treat dry eyes.

Polyethylene glycol 400/propylene glycol ophthalmic is available under the following different brand names: Systane Gel Drops, Systane Preservative-Free, Systane Ultra Preservative-Free, Systane Lubricant Eye Drops, and Systane Ultra.

What Are Dosages of Polyethylene Glycol 400/Propylene Glycol Ophthalmic?

Dosages of Polyethylene Glycol 400/Propylene Glycol Ophthalmic:

Dosage Forms and Strengths

Ophthalmic Drops

  • 0.4%/0.3%

Dosage Considerations – Should be Given as Follows:

Dry Eyes

  • Shake well before use
  • Instill 1-2 drop(s) in affected eye(s) as needed

Safety and efficacy not established in pediatric patients

What Are Side Effects Associated with Using Polyethylene Glycol 400/Propylene Glycol Ophthalmic?

Side effects of polyethylene glycol 400/propylene glycol ophthalmic include:

  • Irritation

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

SLIDESHOW

Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow

What Other Drugs Interact with Polyethylene Glycol 400/Propylene Glycol Ophthalmic?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Polyethylene glycol 400/propylene glycol ophthalmic has no listed severe interactions with other drugs.
  • Polyethylene glycol 400/propylene glycol ophthalmic has no listed serious interactions with other drugs.
  • Polyethylene glycol 400/propylene glycol ophthalmic has no listed moderate interactions with other drugs.
  • Polyethylene glycol 400/propylene glycol ophthalmic has no listed mild interactions with other drugs.
     

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Polyethylene Glycol 400/Propylene Glycol Ophthalmic? 

Warnings
 

This medication contains polyethylene glycol 400/propylene glycol ophthalmic. Do not take Systane Gel Drops, Systane Preservative-Free, Systane Ultra Preservative-Free, Systane Lubricant Eye Drops, or Systane Ultra if you are allergic to polyethylene glycol 400/propylene glycol ophthalmic or any ingredients contained in this drug.


Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Hypersensitivity

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Polyethylene Glycol 400/Propylene Glycol Ophthalmic?”

Long-Term Effects

  • See "What Are Side Effects Associated with Using Polyethylene Glycol 400/Propylene Glycol Ophthalmic?”

Cautions

  • Discontinue if eye pain, vision changes, or persistent irritation/redness occurs
  • Discontinue if condition worsens or persists more than 72 hours

Pregnancy and Lactation

Use polyethylene glycol 400/propylene glycol ophthalmic with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.

It is not known if polyethylene glycol 400/propylene glycol ophthalmic is distributed in milk.

Pregnant or breastfeeding patients should seek advice of a health professional before using over-the-counter (OTC) drugs.

References
https://reference.medscape.com/drug/systane-gel-drops-systane-ultra-polyethylene-glycol-400-propylene-glycol-ophthalmic-999733

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