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Tetracycline

Medical and Pharmacy Editor:

Brand Name: Sumycin, Actisite, Achromycin V

Generic Name: Tetracycline

Drug Class: Tetracyclines

What Is Tetracycline and How Does It Work?

Tetracycline is an antibiotic used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, chlamydia, and others.

Tetracycline is available under the following different brand names: Sumycin, Actisite, and Achromycin V.

Dosages of Tetracycline

Capsule/Tablet

  • 250 mg
  • 500 mg

Syrup (extemporaneously prepared)

  • 125mg/5mL
  • 5 mg

Dosage Considerations – Should be Given as Follows:

Chronic Bronchitis, Acute Exacerbation

  • 500 mg orally every 6 hours

Acne

  • 250-500 mg orally every 12 hours

Ehrlichiosis

  • 500 mg orally every 6 hours for 7-14 days

Vibrio Cholera

  • Adult: 500 mg orally every 6 hours for 3 days
  • Pediatric, Single dose: 25 mg/kg orally; not to exceed 1 g/dose
  • Pediatric, Multiple dose: 40 mg/kg/day orally divided every 6 hours for 3 days; not to exceed 2 g/day

Malaria, Severe Treatment (Unlabeled)

  • Adult: 500 mg orally every 6 hours for 7 days with quinidine gluconate
  • Children under 8 years: Not recommended; tooth discoloration and enamel hypoplasia may occur with use in young children
  • Children over 8 years: 25-50 mg/kg/day orally divided every 6 hours, not to exceed 250 mg/dose every 6 hours for 7 days with quinidine gluconate

Dosage Modifications

Renal impairment

  • CrCl 50-80 mL/min: Dose frequency every 8-12 hours
  • CrCl 10-50 mL/min: Dose frequency every 12-24 hours
  • CrCl less than 10 mL/min: Dose frequency every 24 hours

Dosing Considerations

Susceptible organisms

General Dosing Guidelines, pediatric

  • Children under 8 years: Not recommended; tooth discoloration and enamel hypoplasia may occur with use in young children
  • Children over 8 years: 25-50 mg/kg/day orally divided every 6 hours; not to exceed 3 g/day

Administration

  • Take on empty stomach; do not take with dairy products

What Are Side Effects Associated with Using Tetracycline?

Common side effects of tetracycline include:

Less common side effects of tetracycline include:

Serious side effects of tetracycline include:

This is not a complete list of side effects and other serious side effects may occur. Call your doctor for information and medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What Other Drugs Interact with Tetracycline?

If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Do not start, stop, or change the dosage of this medicine or any medicine before getting further information from your doctor, healthcare provider or pharmacist first.

Severe Interactions of tetracycline include:

Tetracycline has serious interactions with at least 71 different drugs.

Tetracycline has moderate interactions with at least 46 different drugs.

Tetracycline has mild interactions with at least 26 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Tetracycline?

Warnings

This medication contains tetracycline. Do not take Sumycin, Actisite, or Achromycin V if you are allergic to tetracycline or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Tetracycline?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Tetracycline?"

Cautions

  • Photosensitivity may occur with prolonged exposure to sunlight or tanning equipment.
  • Reduce dose in renal impairment.
  • Consider drug serum level determinations in prolonged therapy.
  • Tetracycline use during tooth development (last half of pregnancy through age 8 years) can cause permanent discoloration of teeth.
  • Fanconilike syndrome may occur with outdated tetracyclines.
  • Intravenous/intramuscular (IV/IM) no longer commercially available.

Pregnancy and Lactation

  • Use systemic tetracycline during pregnancy only in LIFE-THREATENING emergencies when no safer drug is available. There is positive evidence of human fetal risk.
  • Use periodontal fiber tetracycline with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • Tetracycline use during tooth development (last half of pregnancy through age 8 years) can cause permanent discoloration of teeth.
  • Tetracycline enters breast milk; some manufacturers say do not nurse; however, the American Academy of Pediatrics (AAP) considers nursing compatible due to calcium chelation of drug and prevention of its absorption (long-term safety of prolonged exposure unknown).
Reviewed on 1/11/2018


Medscape. Tetracycline.
https://reference.medscape.com/drug/tetracycline-342550
RxList. Sumycin Side Effects Drug Center.
https://www.rxlist.com/sumycin-side-effects-drug-center.htm

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