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Tetracycline

Medical and Pharmacy Editor:

Brand Name: Sumycin, Actisite, Achromycin V

Generic Name: Tetracycline

Drug Class: Tetracyclines

What Is Tetracycline and How Does It Work?

Tetracycline is an antibiotic used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, chlamydia, and others.

Tetracycline is available under the following different brand names: Sumycin, Actisite, and Achromycin V.

Dosages of Tetracycline

Capsule/Tablet

  • 250 mg
  • 500 mg

Syrup (extemporaneously prepared)

  • 125mg/5mL
  • 5 mg

Dosage Considerations – Should be Given as Follows:

Chronic Bronchitis, Acute Exacerbation

  • 500 mg orally every 6 hours

Acne

  • 250-500 mg orally every 12 hours

Ehrlichiosis

  • 500 mg orally every 6 hours for 7-14 days

Vibrio Cholera

  • Adult: 500 mg orally every 6 hours for 3 days
  • Pediatric, Single dose: 25 mg/kg orally; not to exceed 1 g/dose
  • Pediatric, Multiple dose: 40 mg/kg/day orally divided every 6 hours for 3 days; not to exceed 2 g/day

Malaria, Severe Treatment (Unlabeled)

  • Adult: 500 mg orally every 6 hours for 7 days with quinidine gluconate
  • Children under 8 years: Not recommended; tooth discoloration and enamel hypoplasia may occur with use in young children
  • Children over 8 years: 25-50 mg/kg/day orally divided every 6 hours, not to exceed 250 mg/dose every 6 hours for 7 days with quinidine gluconate

Dosage Modifications

Renal impairment

  • CrCl 50-80 mL/min: Dose frequency every 8-12 hours
  • CrCl 10-50 mL/min: Dose frequency every 12-24 hours
  • CrCl less than 10 mL/min: Dose frequency every 24 hours

Dosing Considerations

Susceptible organisms

  • Acinetobacter spp, Actinomyces israelii, Afipia felis, Bacillus anthracis, Bacteroides spp, Bartonella bacilliformis, Bartonella quintana, Bordetella pertussis, Borrelia recurrentis, Brucella spp, Capnocytophaga canimorsus, Campylobacter jejuni, Chlamydia spp, Citrobacter spp, Coxiella burnetii, Eikenella corrodens, Escherichia coli, Francisella tularensis, Leptospira interrogans, Helicobacter pylori, Klebsiella spp, Listeria monocytogenes, Moraxella catarrhalis, Mycoplasma pneumoniae, Neisseria gonorrhoeae, Propionibacterium acnes, Rickettsiae, Shigella spp, Staphylococcus aureus, Streptococcus pneumoniae, Treponema pallidum, Ureaplasma urealyticum, Vibrio cholerae, Yersinia pestis, Yersinia enterocolitica, Yersinia pseudotuberculosis

General Dosing Guidelines, pediatric

  • Children under 8 years: Not recommended; tooth discoloration and enamel hypoplasia may occur with use in young children
  • Children over 8 years: 25-50 mg/kg/day orally divided every 6 hours; not to exceed 3 g/day

Administration

  • Take on empty stomach; do not take with dairy products
Medically Reviewed by a Doctor on 1/11/2018



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