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Medical and Pharmacy Editor:

Brand Name: Thalomid

Generic Name: Thalidomide

Drug Class: Antineoplastics, Other; Antineoplastics, Angiogenesis Inhibitor

What Is Thalidomide and How Does It Work?

Thalidomide is used to treat or prevent certain skin conditions related to Hansen's disease, once known as leprosy (erythema nodosum leprosum). Thalidomide is also used to treat a certain type of cancer (multiple myeloma). It works in Hansen's disease by reducing swelling and redness (inflammation). It also reduces the formation of blood vessels that feed tumors.

Thalidomide may also be used to treat certain conditions caused by cancer and HIV infection.

Thalidomide is available under the following different brand names: Thalomid.

Dosages of Thalidomide:

Dosage Forms and Strengths


  • 50 mg
  • 100 mg
  • 150 mg
  • 200 mg

Dosage Considerations – Should be Given as Follows:

Erythema Nodosum Leprosum (ENL)

  • Initial: 100-300 mg orally at bedtime
  • More severe reaction may start at 400 mg
  • Continue until active symptoms subsided, at least 2 weeks, THEN
  • Titrate down by 50 mg increments every 2-4 weeks

Multiple Myeloma

  • 200 mg orally at bedtime in 28-day cycles
  • Take 40 mg of dexamethasone on days 1-4, 9-12, 17-20 of 28 days


  • Take with water at bedtime, at least 1 hour after evening meal
  • Consider dose reduction, delay, or discontinuation in patients who develop NCI CTC (National Cancer Institute Common Toxicity Criteria) Grade 3 or 4 adverse reactions and/or based on clinical judgment

Other Information

Medically Reviewed by a Doctor on 9/6/2017

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