Reviewed on 9/10/2021

What Is Tolterodine and How Does It Work?

Tolterodine is prescribed for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

  • Tolterodine is available under the following different brand names: Detrol, and Detrol LA.

What Are Dosages of Tolterodine?

Dosage Forms and Strengths

Tablet, immediate release

  • 1 mg
  • 2 mg

Capsule, extended-release

  • 2 mg
  • 4 mg

Dosage Considerations – Should be Given as Follows:

Overactive Bladder, Urge Incontinence)

  • Immediate release: 2 mg orally every 12 hours
  • Extended-release: 2-4 mg orally once daily

Renal impairment

  • CrCl 10-30 mL/minute: Not to exceed 1 mg orally every 12 hours (immediate-release) or 2 mg orally once daily (extended-release)
  • CrCl less than 10 mL/minute: Not recommended

Hepatic impairment

  • Mild to moderate (Child-Pugh class A or B): Not to exceed 1 mg orally every 12 hours (immediate-release) or 2 mg orally once daily (extended-release)
  • Severe (Child-Pugh class C): Not recommended

Strong CYP3A4 inhibitors

  • Not to exceed 1 mg orally every 12 hours (immediate-release) or 2 mg orally once daily (extended-release)

Not recommended for pediatric use


Urinary Incontinence in Women: Types, Causes, and Treatments for Bladder Control See Slideshow

What Are Side Effects Associated with Using Tolterodine?

Common side effects of tolterodine include:

Serious side effects of tolterodine include:

  • Vision changes
  • Severe stomach or abdominal pain
  • Trouble urinating
  • Signs of kidney infection (such as burning or painful urination, lower back pain, fever)
  • This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

    What Other Drugs Interact with Tolterodine?

    If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

    This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine.

    What Are Warnings and Precautions for Tolterodine?


    • This medication contains tolterodine. Do not take Detrol or Detrol LA if you are allergic to tolterodine or any ingredients contained in this drug.
    • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


    • Urinary or gastric retention
    • Uncontrolled narrow-angle glaucoma
    • Hypersensitivity to drug or ingredients or to fesoterodine fumarate, which is metabolized to 5-hydroxymethyl tolterodine

    Effects of Drug Abuse

    • None

    Short-Term Effects

    Long-Term Effects

    • See "What Are Side Effects Associated with Using Tolterodine?"


    • Controlled narrow-angle glaucoma, bladder outflow obstruction, gastrointestinal obstruction, hepatic or renal impairment
    • Anaphylaxis and angioedema necessitating hospitalization and emergency treatment reported with first or subsequent doses
    • Anticholinergic central nervous system effects (e.g., dizziness, somnolence) reported; patients should not drive or operate heavy machinery until they adjust to therapy
    • Use with caution in patients with myasthenia gravis, which is characterized by decreased cholinergic activity at the neuromuscular junction
    • When coadministered with strong CYP3A4 inhibitors, tolterodine should be given at a reduced dosage

    Pregnancy and Lactation

    • Use tolterodine with caution during pregnancy if benefits outweigh risks
    • Animal studies show risk and human studies are not available or neither animal nor human studies were done
    • It is unknown whether tolterodine is distributed in breast milk
    • Do not nurse while using tolterodine
    Medscape. Tolterodine.
    RxList. Detrol.

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