Reviewed on 9/1/2021

What Is Torsemide and How Does It Work?

Torsemide is a diuretic used to reduce edema (swelling) from multiple causes such as heart failure, renal disease, or liver disease. Use of torsemide has been found to be effective for the treatment of edema associated with chronic renal failure.

What Are Dosages of Torsemide?

Dosages of Torsemide:

Dosage Forms and Strengths


  • 5 mg
  • 10 mg
  • 20 mg
  • 100 mg

Injectable solution

  • 10 mg/mL

Dosage Considerations – Should be Given as Follows:

Congestive Heart Failure

  • 10-20 mg orally/intravenously once daily initially; doubled until the desired diuretic effect is achieved; individual dose not to exceed 200 mg

Chronic Renal Failure

  • 20 mg orally/intravenously once daily initially; doubled until the desired diuretic effect is achieved; individual dose not to exceed 200 mg

Hepatic Cirrhosis


  • 2.5-5 mg/day orally initially; increased to 10 mg/day orally in 4-6 weeks as needed

Dosing Considerations

  • Use for fluid retention refractory to thiazides or with impaired renal function

Overdose management

  • Normal saline may be used for volume replacement
  • Dopamine or norepinephrine may be used to treat hypotension
  • If dysrhythmia due to decreased potassium or magnesium is suspected, replace aggressively
  • Discontinue treatment if no symptoms are apparent after 6 hours

Pediatric: Safety and efficacy not established


Kidney Stones: Symptoms, Causes, and Treatment See Slideshow

What Are Side Effects Associated with Using Torsemide?

Common side effects of Torsemide include:

Less common side effects of torsemide include:

Serious side effects of torsemide include:

Postmarketing side effects of torsemide reported include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Torsemide?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Torsemide has no known severe interactions with other drugs.
  • Serious interactions of torsemide include:
  • Torsemide has moderate interactions with at least 150 different drugs.
  • Torsemide has mild interactions with at least 76 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine.

What Are Warnings and Precautions for Torsemide?


This medication contains torsemide. Do not take Demadex if you are allergic to torsemide or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


  • Known hypersensitivity to torsemide or to povidone
  • Anuria
  • Hepatic coma

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Torsemide?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Torsemide?"


  • Use with caution in diabetes mellitus, fluid or electrolyte imbalance (hypokalemia, hyponatremia), hyperglycemia, hyperlipidemia, hyperuricemia or gout, severe liver disease with cirrhosis and ascites
  • Use with caution in cirrhosis; avoid changes in fluid and electrolyte balance and acid-base status, which may lead to hepatic encephalopathy
  • Monitor fluid status and renal function to prevent azotemia, oliguria, and reversible increases in blood urea nitrogen (BUN) and creatinine
  • Excessive diuresis may cause potentially symptomatic dehydration, blood volume reduction, and hypotension, and worsening renal function, including acute renal failure particularly in salt-depleted patients or those taking renin-angiotensin-aldosterone inhibitors; worsening of renal function can also occur with concomitant use of nephrotoxic drugs (e.g., aminoglycosides, cisplatin, and nonsteroidal anti-inflammatory drugs [NSAIDs]); monitor volume status and renal function periodically
  • Can cause potentially symptomatic hypokalemia, hyponatremia, hypomagnesemia, hypocalcemia, and hypochloremic alkalosis; therapy can cause an increase in blood glucose levels and hyperglycemia; asymptomatic hyperuricemia can occur and gout may rarely be precipitated; monitor serum electrolytes and blood glucose periodically
  • Tinnitus and hearing loss (ototoxicity; usually reversible) have been observed with loop diuretics; higher than recommended doses, severe renal impairment, and hypoproteinemia, appears to increase the risk of ototoxicity

Pregnancy and Lactation

  • There are no available data on the use of torsemide in pregnant women and the risk of major birth defects or miscarriage. However, in pregnant rats and rabbits administered 50 and 6.8 times the human dose, respectively, decreases in body weight, decreased fetal resorption, and delayed fetal ossification were observed
  • There are no data regarding the presence of torsemide in human milk or effects on the breastfed child
  • Diuretics can suppress lactation
  • Consult your doctor before breastfeeding


The only purpose of the kidneys is to filter blood. See Answer
Medscape. Torsemide.
RxList. Demadex.

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